PMID: 2123758Nov 1, 1990Paper

Bio and immuno-activity of FSH in serum after intramuscular injection of highly purified urinary human FSH in normal men

Clinical Endocrinology
F JockenhövelE Nieschlag

Abstract

The pharmacokinetics of a human FSH preparation widely used in clinical practice was evaluated in healthy male volunteers whose endogenous FSH was suppressed by 19-nortestosterone injections. 9.7 h following intramuscular injection of 150 IU FSH the mean immunoreactive peak concentration over baseline was 3.8 IU/1. Injection of 450 IU FSH led to a mean immunoreactive peak level of 10.4 IU/1 at 9.8 h. Mean half-life was 24.6 h (150 IU FSH) and 32.6 h (450 IU FSH). Serum bioFSH concentrations were suppressed below the detection limit after injection of the 19-nortestosterone and rose to preinjection levels after administration of FSH. Mean bioactive peak level for the 450 IU FSH was 7.3 IU/1 FSH at 7.4 h. The half-life of bioFSH was calculated to be 13.4 h and is considerably shorter than the half-life of immunoFSH. Serum inhibin levels were suppressed by 19-nortestosterone and did not change significantly after injection of the FSH preparation, suggesting that the FSH dose was insufficient to elicit this biological response. It is concluded that the currently used dose regimen for the treatment of male hypogonadism is inadequate for maintenance of serum bioFSH levels in the normal range.

References

Mar 1, 1989·The Journal of Endocrinology·D M de KretserH G Burger
Dec 1, 1989·Acta Endocrinologica·F JockenhövelE Nieschlag
Feb 1, 1987·Fertility and Sterility·V SharmaM Whitehead
Oct 1, 1987·The Journal of Clinical Endocrinology and Metabolism·C WangA J Hsueh
Jan 1, 1988·Human Reproduction·E Diczfalusy, J Harlin
Aug 1, 1988·Endocrine Reviews·C Wang
Sep 1, 1988·The Journal of Clinical Endocrinology and Metabolism·D M RobertsonJ K Findlay
Nov 1, 1987·The Journal of Clinical Endocrinology and Metabolism·R I McLachlanD M de Kretser
May 1, 1985·Journal of Steroid Biochemistry·L BelkienE Nieschlag
Mar 1, 1970·The Journal of Clinical Endocrinology and Metabolism·S C YenA S Littell
Jan 1, 1983·Acta Endocrinologica·G Verhoeven, P Franchimont
Jan 1, 1983·Endocrine Reviews·S C ChappelC Coutifaris
Oct 1, 1982·International Journal of Andrology·W B SchillS Braun
Nov 1, 1982·Molecular and Cellular Endocrinology·F Le Gac, D M de Kretser

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Citations

Dec 1, 1991·Journal of Endocrinological Investigation·M Simoni, E Nieschlag
Feb 1, 1993·Clinical Endocrinology·E Nieschlag
Sep 1, 1991·Clinical Endocrinology·A TsatsoulisW R Robertson
Jan 1, 1991·Annals of the New York Academy of Sciences·G F Weinbauer, E Nieschlag
Feb 23, 2019·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·Timothy W ChowHarvey Wong
Jun 30, 2004·Journal of Andrology·Axel KamischkeEberhard Nieschlag
Jun 1, 1996·International Journal of Andrology·C RolfE Nieschlag
Aug 3, 1992·The Medical Journal of Australia·D J Handelsman

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