Bio and phyto-chemical effect of Amphora coffeaeformis extract against hepatic injury induced by paracetamol in rats

Molecular Biology Reports
Abo El-Khair B El-SayedMohamed M Seif

Abstract

Paracetamol is the most commonly used analgesic-antipyretic drugs. Its excess use causes an acute hepatotoxicity. It is well known that the Bacillariophyta alga Amphora coffeaeformis is rich in many photosynthetic pigments with antioxidant activities as well as a series of biologically active substances. The current work has been designed to study the phytochemical composition of different A. coffeaeformis algal extracts to select the most effective one. It was verified that acetone A. coffeaeformis algal extract is rich in various pigments and polyphenolic compounds (β-carotene (9.31 ± 0.06 mg·g-1), gallic acid (28.31 µg·g-1), catechin (38.08 µg·g-1) and p-coumaric acid (38.69 µg·g-1)). The pigments and phenolic profiles in acetone extract were determined in addition to isolation of β-carotene and fucoxanthin which exhibited free radical scavenging activity by 74.80% and 69.40%, respectively. Therefore, the highest total antioxidant capacity and free radical scavenging activity were noticed with this extract. Consequently, efficiency of this algal extract was evaluated against hepatic intoxication induced by paracetamol in rats. The biochemical measurements (liver functions and markers of oxidative stress) were  assayed. Moreo...Continue Reading

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Citations

Mar 18, 2020·Molecular Biology Reports·Mai M Al-OqailAbdulaziz A Al-Khedhairy
Nov 24, 2020·Environmental Science and Pollution Research International·Marwa E HassanMosaad A Abdel-Wahhab
Jul 20, 2021·Environmental Science and Pollution Research International·Rania F IsmailAlaa El-Din H Sayed

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Methods Mentioned

BETA
chip
Electrophoresis
glycosylation

Software Mentioned

Statistical Package for Social Sciences ( SPSS
Quantity One

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