Bio-based building blocks from 5-hydroxymethylfurfural via 1-hydroxyhexane-2,5-dione as intermediate

Chemical Science
Bartosz WozniakJohannes G de Vries

Abstract

The limits to the supply of fossil resources and their ever increasing use forces us to think about future scenarios for fuels and chemicals. The platform chemical 5-hydroxymethyl-furfural (HMF) can be obtained from biomass in good yield and has the potential to be converted in just a few steps into a multitude of interesting products. Over the last 20 years, the conversion of HMF to 1-hydroxyhexane-2,5-dione (HHD) has been studied by several groups. It is possible to convert HMF into HHD by hydrogenation/hydrolytic ring opening reaction in aqueous phase using various heterogeneous and homogeneous catalysts. This review addresses both the state of the art of HHD synthesis, including mechanistic aspects of its formation, as well as the recent progress in the application of HHD as a building block for many useful chemicals including pyrroles, cyclopentanone derivatives and triols.

References

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May 31, 2007·Chemical Reviews·Avelino CormaAlexandra Velty
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Citations

Oct 2, 2019·Chemistry, an Asian Journal·Liam J DonnellyJason B Love
May 31, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Yanliang YangYing Duan
Jul 16, 2020·Chemical Reviews·Romaric GérardyJean-Christophe M Monbaliu
Sep 23, 2021·Chemical Communications : Chem Comm·Andrea Dell'AcquaJohannes G de Vries

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Methods Mentioned

BETA
column chromatography
X-ray

Software Mentioned

Ava
Biochem

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