Bio-based production of monomers and polymers by metabolically engineered microorganisms

Current Opinion in Biotechnology
Hannah ChungSang Yup Lee

Abstract

Recent metabolic engineering strategies for bio-based production of monomers and polymers are reviewed. In the case of monomers, we describe strategies for producing polyamide precursors, namely diamines (putrescine, cadaverine, 1,6-diaminohexane), dicarboxylic acids (succinic, glutaric, adipic, and sebacic acids), and ω-amino acids (γ-aminobutyric, 5-aminovaleric, and 6-aminocaproic acids). Also, strategies for producing diols (monoethylene glycol, 1,3-propanediol, and 1,4-butanediol) and hydroxy acids (3-hydroxypropionic and 4-hydroxybutyric acids) used for polyesters are reviewed. Furthermore, we review strategies for producing aromatic monomers, including styrene, p-hydroxystyrene, p-hydroxybenzoic acid, and phenol, and propose pathways to aromatic polyurethane precursors. Finally, in vivo production of polyhydroxyalkanoates and recombinant structural proteins having interesting applications are showcased.

References

Jan 1, 1996·International Journal of Systematic Bacteriology·C Fischer-RomeroF Jüttner
Oct 29, 2003·Current Opinion in Biotechnology·Charles E Nakamura, Gregory M Whited
Mar 7, 2006·Applied and Environmental Microbiology·Sang Jun LeeSang Yup Lee
Sep 9, 2008·Applied Microbiology and Biotechnology·Shohei OkinoHideaki Yukawa
Aug 29, 2009·Biotechnology and Bioengineering·Zhi-Gang QianSang Yup Lee
Nov 26, 2009·Biotechnology and Bioengineering·Yu Kyung JungSang Yup Lee
Jul 28, 2010·Proceedings of the National Academy of Sciences of the United States of America·Xiao-Xia XiaSang Yup Lee
Sep 3, 2010·Biotechnology and Bioengineering·Zhi-Gang QianSang Yup Lee
May 24, 2011·Nature Chemical Biology·Harry YimStephen Van Dien
Jul 5, 2011·Metabolic Engineering·Rebekah McKenna, David R Nielsen
Apr 24, 2012·Current Opinion in Biotechnology·Hannah ChungSang Yup Lee
Jul 4, 2012·Applied and Environmental Microbiology·Daisuke KomaKiyofumi Sakai
Jul 25, 2012·Journal of Biotechnology·Tino PolenMichael Bott
Sep 27, 2012·Bioprocess and Biosystems Engineering·Si Jae ParkJonggeon Jegal
Nov 13, 2012·Metabolic Engineering·Daniel E AgnewBrian F Pfleger
Dec 13, 2012·Applied Microbiology and Biotechnology·Huaiwei LiuWook-Jin Chung
Jan 22, 2013·Nature Biotechnology·Dokyun NaSang Yup Lee
Oct 12, 2013·Biotechnology Journal·Byoungjin KimSang Yup Lee
Feb 11, 2014·Journal of Industrial Microbiology & Biotechnology·Ming LiFuping Lu
Jun 3, 2014·Biomacromolecules·Tony CollinsMargarida Casal
Jun 5, 2014·Biotechnology and Bioengineering·Jia-Le YuZhi-Gang Qian
Jul 19, 2014·Bioprocess and Biosystems Engineering·Rebekah McKennaDavid R Nielsen
Jul 30, 2014·Biomacromolecules·Dawei DingAli Miserez
Sep 18, 2014·Nature Communications·Peter Q NguyenNeel S Joshi
Dec 6, 2014·Macromolecular Bioscience·Melik C DemirelHuihun Jung
Dec 11, 2014·Microbial Cell Factories·Yudong JiangMo Xian
Feb 5, 2015·Journal of Bioscience and Bioengineering·Hiroshi HonjoTaizo Hanai

❮ Previous
Next ❯

Citations

Mar 12, 2016·Science·Uwe T Bornscheuer
Apr 19, 2016·ACS Synthetic Biology·Yunjie LiY-H Percival Zhang
May 18, 2016·Journal of Biotechnology·Marko KirtzBernhard Hauer
Aug 2, 2016·Microbial Biotechnology·Auxiliadora Prieto
Oct 5, 2016·ACS Synthetic Biology·Takuya MatsumotoAkihiko Kondo
Jun 7, 2017·FEMS Yeast Research·Quinten DeparisJohan M Thevelein
Nov 18, 2017·Science·Marc A Hillmyer
Aug 2, 2017·Biotechnology Journal·Anna N KhusnutdinovaAlexander F Yakunin
Nov 20, 2018·Biotechnology and Bioengineering·Yun-Gi HongYung-Hun Yang
Oct 12, 2017·Nature Biotechnology·Jonathan M MonkBernhard O Palsson
Apr 14, 2020·Biotechnology and Bioengineering·So Young ChoiSang Yup Lee
Oct 24, 2019·Mini Reviews in Medicinal Chemistry·Mengxun ShiMo Xian
Mar 11, 2020·Annual Review of Chemical and Biomolecular Engineering·Jiajie Huo, Brent H Shanks
Nov 15, 2018·Frontiers in Microbiology·Fernando Pérez-GarcíaVolker F Wendisch
Jul 24, 2018·Engineering in Life Sciences·Jia-Le YuJian-Jiang Zhong
Nov 12, 2017·Applied Microbiology and Biotechnology·Jia WangYajun Yan
May 12, 2021·Microbial Cell Factories·Carina PrellVolker F Wendisch
May 19, 2021·Critical Reviews in Biotechnology·Patrycja SzczepańskaZbigniew Lazar
Jul 2, 2021·Materials Today. Bio·O Burgos-MoralesW Weber
Apr 12, 2018·Journal of Agricultural and Food Chemistry·Hyun Gyu LimGyoo Yeol Jung
May 11, 2019·ACS Synthetic Biology·Sungyeon JangGyoo Yeol Jung
Nov 20, 2019·ACS Synthetic Biology·Christopher Hyde BowenFuzhong Zhang
Mar 14, 2018·Biochemistry·Hanan L MessihaNigel S Scrutton

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.