Bio-conjugation of antioxidant peptide on surface-modified gold nanoparticles: a novel approach to enhance the radical scavenging property in cancer cell

Cancer Nanotechnology
Sushma KalmodiaSailaja V Elchuri

Abstract

Functionalized gold nanoparticles are emerging as a promising nanocarrier for target specific delivery of the therapeutic molecules in a cancer cell, as a result it targeted selectively to the cancer cell and minimized the off-target effect. The functionalized nanomaterial (bio conjugate) brings novel functional properties, for example, the high payload of anticancer, antioxidant molecules and selective targeting of the cancer molecular markers. The current study reported the synthesis of multifunctional bioconjugate (GNPs-Pep-A) to target the cancer cell. The GNPs-Pep-A conjugate was prepared by functionalization of GNPs with peptide-A (Pro-His-Cys-Lys-Arg-Met; Pep-A) using thioctic acid as a linker molecule. The GNPs-Pep-A was characterized and functional efficacy was tested using Retinoblastoma (RB) cancer model in vitro. The GNPs-Pep-A target the reactive oxygen species (ROS) in RB, Y79, cancer cell more effectively, and bring down the ROS up to 70 % relative to control (untreated cells) in vitro. On the other hand, Pep-A and GNPs showed 40 and 9 % reductions in ROS, respectively, compared to control. The effectiveness of bioconjugate indicates the synergistic effect, due to the coexistence of both organic (Pep-A) and inorg...Continue Reading

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Citations

May 24, 2019·Aging·Chun-Shuang XuLi-Li Zang
May 1, 2019·Current Pharmaceutical Biotechnology·Abbas H AzandaryaniTahereh Jamshidnejad-Tosaramandani
Nov 20, 2018·Nano Research·Carolina A FerreiraWeibo Cai
Jun 27, 2019·Drug Development and Industrial Pharmacy·V R RanjithaV Ravishankar Rai

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Methods Mentioned

BETA
surface plasmon resonance
Assay
dynamics
dynamic light scattering
fluorescence microscopy
FACS
PCR
environmental stress
flow cytometry

Software Mentioned

CELL QUEST PRO
SDS

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