Bio-inspired Nonheme Iron Oxidation Catalysis: Involvement of Oxoiron(V) Oxidants in Cleaving Strong C-H Bonds.

Angewandte Chemie
Subhasree KalLawrence Que

Abstract

Nonheme iron enzymes generate powerful and versatile oxidants that perform a wide range of oxidation reactions, including the functionalization of inert C-H bonds, which is a major challenge for chemists. The oxidative abilities of these enzymes have inspired bioinorganic chemists to design synthetic models to mimic their ability to perform some of the most difficult oxidation reactions and study the mechanisms of such transformations. Iron-oxygen intermediates like iron(III)-hydroperoxo and high-valent iron-oxo species have been trapped and identified in investigations of these bio-inspired catalytic systems, with the latter proposed to be the active oxidant for most of these systems. In this Review, we highlight the recent spectroscopic and mechanistic advances that have shed light on the various pathways that can be accessed by bio-inspired nonheme iron systems to form the high-valent iron-oxo intermediates.

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Citations

Oct 31, 2020·Chemistry : a European Journal·Jonas F SchlagintweitFritz E Kühn
Nov 19, 2020·Angewandte Chemie·Hai-Xu WangChi-Ming Che
Dec 15, 2020·Chemical Society Reviews·Shunichi FukuzumiWonwoo Nam
Mar 13, 2021·Advanced Materials·Shuai ZhangChun-Hua Yan
Dec 8, 2020·ACS Catalysis·Noah P Dunham, Frances H Arnold
Mar 30, 2021·Chemistry : a European Journal·Alexandra M ZimaEvgenii P Talsi
Aug 14, 2020·Journal of the American Chemical Society·Shan-Shan XueWonwoo Nam
Nov 14, 2020·Journal of the American Chemical Society·Lina ZhangWonwoo Nam
Sep 8, 2021·Inorganic Chemistry·Justin L LeeA S Borovik
Oct 6, 2021·Journal of the American Chemical Society·Jindou YangWonwoo Nam

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