Bio-inspired synthetic receptor molecules towards mimicry of vancomycin

Bioorganic & Medicinal Chemistry Letters
M C MonneeR M Liskamp


A 512-member library of bio-inspired synthetic receptor molecules was prepared featuring a triazacyclophane scaffold. The purpose of this scaffold was to orient three (identical) peptide 'binding arms' in order to mimic an antibiotic binding cavity as is present in the vancomycin antibiotics. The library was screened with D-Ala-D-Ala and D-Ala-D-Lac containing ligands, which are present in the cell wall precursors of pathogenic bacteria. Screening and validation led to identification of a synthetic receptor capable of binding these ligands.


Jan 17, 2012·Journal of Medicinal Chemistry·Christopher J ArnuschYechiel Shai
Apr 23, 2004·Organic Letters·Aaron T Wright, Eric V Anslyn


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Related Concepts

Combinatorial Chemistry Techniques
Bacteriocidal Agents
Pathogenic Organism
Vancomycin Assay
Body Cavities

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