Bio-Nano-Magnetic Materials for Localized Mechanochemical Stimulation of Cell Growth and Death

Advanced Materials
Devrim KilincGil U Lee

Abstract

Magnetic nanoparticles are promising new tools for therapeutic applications, such as magnetic nanoparticle hyperthermia therapy and targeted drug delivery. Recent in vitro studies have demonstrated that a force application with magnetic tweezers can also affect cell fate, suggesting a therapeutic potential for magnetically modulated mechanical stimulation. The magnetic properties of nanoparticles that induce physical responses and the subtle responses that result from mechanically induced membrane damage and/or intracellular signaling are evaluated. Magnetic particles with various physical, geometric, and magnetic properties and specific functionalization can now be used to apply mechanical force to specific regions of cells, which permit the modulation of cellular behavior through the use of spatially and time controlled magnetic fields. On one hand, mechanochemical stimulation has been used to direct the outgrowth on neuronal growth cones, indicating a therapeutic potential for neural repair. On the other hand, it has been used to kill cancer cells that preferentially express specific receptors. Advances made in the synthesis and characterization of magnetic nanomaterials and a better understanding of cellular mechanotransduc...Continue Reading

References

Aug 1, 1992·The Journal of Cell Biology·P LamoureuxS R Heidemann
Oct 6, 2001·Science·S R Nicewarner-PenaM J Natan
Jun 11, 2004·American Journal of Physiology. Cell Physiology·P J MackR D Kamm
Sep 10, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Bryan J PfisterDouglas H Smith
Jul 1, 2005·Nature·Bernhard Gleich, Jürgen Weizenecker
Aug 2, 2005·Nature Reviews. Cancer·Britta WeigeltLaura J van 't Veer
Sep 7, 2005·Current Opinion in Neurobiology·Katherine Kalil, Erik W Dent
Oct 6, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Sally J DeNardoRobert Ivkov
Nov 30, 2005·Journal of Neuro-oncology·Andreas JordanRoland Felix
Dec 13, 2005·Biophysical Journal·Guoying JiangMichael P Sheetz
Apr 12, 2006·Nature Reviews. Molecular Cell Biology·Viola Vogel, Michael Sheetz
May 13, 2006·Annual Review of Biophysics and Biomolecular Structure·Viola Vogel
Jul 17, 2007·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Gerald L DeNardoRodney L Balhorn
Jan 10, 2008·Proceedings of the National Academy of Sciences of the United States of America·Boris PolyakRobert J Levy
Jul 9, 2008·Developmental Cell·Andrew W SchaeferPaul Forscher
May 20, 1996·Biotechnology and Bioengineering·D J OddeH M Buettner
Jul 26, 2008·Nature Nanotechnology·Robert J MannixDonald E Ingber
Jan 31, 2009·Science·Armando del RioMichael P Sheetz
Feb 20, 2009·Nature·Randall M ErbBenjamin B Yellen
Apr 30, 2009·Journal of Cell Science·Julien ColombelliErnst H K Stelzer
Aug 29, 2009·Biomaterials·Vincent H B HoNigel K H Slater
Dec 1, 2009·Nature Materials·Dong-Hyun KimValentyn Novosad
May 13, 2010·Journal of the American Chemical Society·Shang-Hsiu Hu, Xiaohu Gao
Jul 24, 2010·IEEE Transactions on Nanobioscience·Glen R KirkhamSarah Harriet Cartmell
Jan 15, 2011·Physical Review Letters·Joel B RovnerRobert L Leheny
Apr 30, 2011·Progress in Neurobiology·Daniel M Suter, Kyle E Miller
May 17, 2011·Nature Cell Biology·Christophe GuilluyKeith Burridge
Jun 28, 2011·Nature Reviews. Cancer·Denis WirtzPeter C Searson
Jul 19, 2011·Developmental Cell·Jeroen EyckmansChristopher S Chen
Jul 22, 2011·Nature·Brenton D HoffmanMartin A Schwartz
Oct 14, 2011·Bioinspiration & Biomimetics·P SchroederH Brückl
Nov 4, 2011·Langmuir : the ACS Journal of Surfaces and Colloids·Yong ZhangGil U Lee
Feb 22, 2012·Neuroscience Letters·Dylan A McCreedy, Shelly E Sakiyama-Elbert

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Citations

Aug 25, 2016·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Ekaterina Igorevna ShishatskayaNatalia Gennadievna Menzianova
Jun 10, 2017·Nature Communications·Amalio Fernández-PachecoRussell P Cowburn
May 2, 2017·Tissue Engineering. Part B, Reviews·Manuela E GomesRui L Reis
Oct 5, 2019·Regenerative Medicine·Yun QianCunyi Fan
Sep 10, 2019·Analytical Sciences : the International Journal of the Japan Society for Analytical Chemistry·Hitoshi WataraiHana Subhan Memon Sakurai
Apr 30, 2017·Analytical and Bioanalytical Chemistry·Pengfei ZhaoHuiying Zhao
Jun 6, 2018·Frontiers in Neuroscience·Trevor J Gahl, Anja Kunze
Apr 13, 2021·Journal of Biomaterials Applications·Valerii B OrelValerii E Orel
Oct 8, 2020·Langmuir : the ACS Journal of Surfaces and Colloids·Hitoshi Watarai, Sana Subhan Memon Sakurai

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