Bio-surface coated titanium scaffolds with cancellous bone-like biomimetic structure for enhanced bone tissue regeneration

Acta Biomaterialia
Bingjun ZhangJie Weng

Abstract

In view of the fact that titanium (Ti)-based implants still face the problem of loosening and failure of the implants caused by the slow biological response, the low osseointegration rate and the implant bacterial infection in clinical application, we designed a cancellous bone-like biomimetic Ti scaffold using the template accumulated by sugar spheres as a pore-forming agent. And based on a modified surface mineralization process and mussel-like adhesion mechanism, a silicon-doped calcium phosphate composite coating (Van-pBNPs/pep@pSiCaP) with Vancomycin (Van)-loaded polydopamine (pDA)-modified albumin nanoparticles (Van-pBNPs) and cell adhesion peptides (GFOGER) was constructed on the surface of Ti scaffold for mimicking the extracellular matrix (ECM) microenvironment of natural bone matrix to induce greater tissue regeneration. The in vitro study demonstrated that this porous Ti scaffold with functional bio-surface could distinctly facilitate cell early adhesion and spreading, and activate the expression of α2β1 integrin receptor on the cell membrane through promoting the formation of focal adhesions (FAs) in bone marrow stromal cells (BMSCs), thus mediating greater osteogenic cell differentiation. And it could also effectiv...Continue Reading

Citations

Mar 6, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Zheng-Yang ChenFang Zhou
May 9, 2021·Colloids and Surfaces. B, Biointerfaces·Zheng WangQihui Zhou
May 25, 2021·Bioengineering & Translational Medicine·Sijing JiangJiacai He
Jun 5, 2021·Acta Biomaterialia·Zhurong TangXingdong Zhang

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