Bio-synthesized sardine oil concentrate alters the composition of hepatic lipids in rats: A lipidomic approach.

Food Research International
Mari UyedaPatricia de Oliveira Carvalho

Abstract

Both preventive and curative therapies have created a considerable demand for n-3 PUFAs (polyunsaturated fatty acids) from fish oil, such as eicosapentaenoic (EPA) and docosahexaenoic (DHA) acids, for human use. Bio-synthesized sardine oil (bioSO) concentrate containing an acylglycerols mixture with 50% n-3 PUFAs was obtained by Candida cylindracea lipase hydrolysis and subsequently used for in vivo tests in animals. Wistar rats received, by gavage, a dose of 0.2 g/kg/day of bioSO or unmodified sardine oil (unSO) or saline solution (control) for three consecutive days and the liver tissue was evaluated by a selective and sensitive lipidomic approach based on ultra-performance liquid chromatography-quadruple time-of-flight mass spectrometry (UPLC-QTOF-MSE) and gas chromatography (GC). In addition, antioxidant parameters, response of oxidative stress marker and estimated fatty acid desaturase indexes were determined. The use of bioSO led to an increase in Cer d18:1/16:0, PE-Cer d14:2/18:0 and highly unsaturated phosphatylcholines (PC 38:4, PC 40:6 and PC 42:8) in the hepatic tissue membranes. There was also an increase in DHA incorporation in animals that received bioSO in comparison with the control animals. No differences in su...Continue Reading

References

Jun 1, 1979·Analytical Biochemistry·H OhkawaK Yagi
Jul 1, 1970·Physiological Reviews·A Deisseroth, A L Dounce
May 25, 2002·Journal of Nutritional Science and Vitaminology·Fumiaki BannoKenshiro Fujimoto
Apr 2, 2013·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Karina V BarrosVera L F Silveira
Feb 20, 2014·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Oskar L KnittelfelderGerald N Rechberger
Sep 23, 2014·Biochimica Et Biophysica Acta·Woo-Jae ParkAnthony H Futerman
Mar 11, 2015·Journal of Physiology and Biochemistry·Silvia Lorente-CebriánMaría J Moreno-Aliaga
Jul 1, 2016·JAMA Internal Medicine·Liana C Del GobboUNKNOWN Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Fatty Acids and Outcomes Research Consortium (FORCe)
Aug 17, 2016·Brazilian Journal of Microbiology : [publication of the Brazilian Society for Microbiology]·Maria Elisa Melo Branco de AraújoPatrícia de Oliveira Carvalho
Nov 15, 2016·Annals of Nutrition & Metabolism·Philip C Calder
Feb 8, 2018·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Agnieszka StawarskaAndrzej Tokarz
Jul 20, 2018·Lipids in Health and Disease·So Hyun AhnSung Hee Han
Jun 23, 2019·Journal of the Science of Food and Agriculture·Jeyakumar BalakrishnanKathiresan Shanmugam
Aug 7, 2019·International Journal of Food Sciences and Nutrition·Jing WangChun Li

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.