Bio-transformation of artemisinin using soil microbe: Direct C-acetoxylation of artemisinin at C-9 by Penicillium simplissimum.

Bioorganic & Medicinal Chemistry Letters
Abhishek GoswamiMadhunika Sharma

Abstract

Potent antimalarial compound artemisinin, 1 was bio-transformed to C-9 acetoxy artemisinin, 2 using soil microbe Penicillium simplissimum along with C-9 hydroxy derivative 3. The products were characterized using high field NMR and MS-MS data. The absolute stereochemistry of the newly generated chiral centers has been ascertained by COSY and 1D NOESY experiments. This is the first Letter of direct C-acetoxylation of artemisinin using microbial strains.

References

Jan 30, 2010·Chemical Society Reviews·Devdutt ChaturvediParuchuri G Rao

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Citations

Dec 14, 2012·Future Medicinal Chemistry·Nyaradzo T L Chigorimbo-MurefuKelly Chibale
Feb 26, 2015·Applied Microbiology and Biotechnology·Yulian ZhanJohn S Williamson
Aug 3, 2011·Natural Product Reports·Braulio M Fraga
Jun 19, 2015·Molecular Diversity·Naresh SurineniNabin C Barua
Aug 5, 2017·Bioresources and Bioprocessing·Hongchang YuYulian Zhan
Jan 19, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Yue MaLan Yang
Jan 5, 2011·Molecular Diversity·Abhishek GoswamiNabin C Barua
Mar 31, 2021·Journal of Asian Natural Products Research·Nurul Iman AminudinZaima Azira Zainal Abidin
Sep 20, 2018·Journal of Agricultural and Food Chemistry·Mangala Gowri PonnapalliPuran Singh Sijwali

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