PMID: 9428108Jan 15, 1998Paper

Bioaccumulation and clearance of microcystins from salt water mussels, Mytilus edulis, and in vivo evidence for covalently bound microcystins in mussel tissues

Toxicon : Official Journal of the International Society on Toxinology
D WilliamsC F Holmes

Abstract

Over a period of 3 days saltwater mussels, Mytilus edulis, were fed a cyanobacteria, Microcystis aeruginosa, that contained a high concentration of microcystins. The mussels were killed on a periodic basis over the course of 2 months. Mussels were also collected at two sites were high levels of microcystins in tissues had been noted. A strategy based on the chemically unique nature of the C20 beta-amino acid, (2S,3S,8S,9S)-3-amino-9-methoxy-2,6,8-trimethyl-10-phenyldeca-4,6- dienoic acid (Adda), portion of the microcystins was used in conjunction with a protein phosphatase (PPase) assay to analyse for both covalently bound microcystins and free microcystins in the mussel tissues. The mussel PPase assay results were compared with the Lemieux oxidation gas chromatography-mass spectrometry (GCMS) analysis. Less than 0.1% of the total microcystin burden in the mussel tissue was found to be extractable with MeOH. Thus, direct evidence was provided for the existence of covalently bound microcystins in mussel tissues in vivo. The mussels rapidly cleared the covalently bound microcystins when transferred to untreated seawater. Within 4 days the total microcystin burden dropped from a high of 336.9 (+/- 45.8) micrograms/g wet tissue to ...Continue Reading

References

Jan 1, 1992·Journal of Cancer Research and Clinical Oncology·R Nishiwaki-MatsushimaH Fujiki
Jun 1, 1992·The Journal of Applied Bacteriology·W W Carmichael
Sep 1, 1991·Japanese Journal of Cancer Research : Gann·R Nishiwaki-MatsushimaH Fujiki
Jan 1, 1991·Journal of Biochemical Toxicology·N A RobinsonJ G Pace
Jan 1, 1990·Journal of Cancer Research and Clinical Oncology·S YoshizawaH Fujiki
May 28, 1983·The Medical Journal of Australia·I R FalconerM T Runnegar
Nov 2, 1995·Biochemical and Biophysical Research Communications·M RunnegarL Zhang
Feb 1, 1995·Toxicon : Official Journal of the International Society on Toxinology·D E WilliamsC F Holmes
Feb 1, 1995·Nature Structural Biology·J R BaguC F Holmes
Dec 1, 1993·Toxicon : Official Journal of the International Society on Toxinology·M CraigC F Holmes
Jan 1, 1994·Scientific American·W W Carmichael
Oct 1, 1993·Toxicon : Official Journal of the International Society on Toxinology·R J AndersenD E Williams
Nov 1, 1993·Toxicon : Official Journal of the International Society on Toxinology·D Z ChenC F Holmes
Jan 1, 1993·Toxicon : Official Journal of the International Society on Toxinology·H A LuuC F Holmes
May 11, 1996·BMJ : British Medical Journal·J Dunn
Jun 1, 1996·Toxicon : Official Journal of the International Society on Toxinology·K HaradaF Kondo
Jan 1, 1996·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·M CraigC F Holmes
Apr 1, 1997·Chemical Research in Toxicology·D E WilliamsR J Andersen

❮ Previous
Next ❯

Citations

Jan 7, 2009·Archives of Environmental Contamination and Toxicology·Fu-Gang XiaoWei-Min Niu
Oct 16, 2003·Toxicon : Official Journal of the International Society on Toxinology·V F MagalhãesS M F O Azevedo
Jan 27, 1999·Toxicon : Official Journal of the International Society on Toxinology·C SallenaveJ F Verbist
Jul 20, 2002·Aquatic Toxicology·Aloysio da S Ferrão-FilhoSandra M F O Azevedo
Dec 31, 2002·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Krister KarlssonJussi Meriluoto
Jan 2, 2009·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·José C Martins, Vítor M Vasconcelos
Nov 26, 2009·Bulletin of Environmental Contamination and Toxicology·Dawen ZhangJun Chen
Feb 4, 2012·Environmental Toxicology and Pharmacology·Yan Li, Xiaodong Han
Apr 12, 2011·Ecotoxicology and Environmental Safety·Sebastián E SabatiniMaría Del Carmen Ríos de Molina
Jan 15, 2010·Ecotoxicology and Environmental Safety·Juliette L SmithGregory L Boyer
Apr 21, 2009·Toxicon : Official Journal of the International Society on Toxinology·Guifang DongShouqi Xie
Jul 19, 2008·Ecotoxicology and Environmental Safety·Dawen ZhangZhourui Wen
Feb 1, 2008·Ecotoxicology and Environmental Safety·Hichem NasriNoureddine Bouaïcha
Dec 11, 2007·Toxicon : Official Journal of the International Society on Toxinology·Charles P DebloisDavid F Bird
Feb 4, 2009·Journal of Experimental Zoology. Part A, Ecological Genetics and Physiology·Sandra FernandesVitor Manuel Vasconcelos
Oct 24, 2009·Environmental Toxicology·Guifang DongShouqi Xie
Nov 30, 2011·Analytica Chimica Acta·Xingqiang WuJingshuang Liu
Aug 18, 2004·Aquatic Toxicology·L M Dionisio PiresB W Ibelings
Apr 22, 2006·Toxicon : Official Journal of the International Society on Toxinology·Jennifer L Ott, Wayne W Carmichael
Jan 13, 2006·Ecotoxicology and Environmental Safety·Zakaria A Mohamed, Ahmed A Hussein
Dec 3, 2014·Environmental Pollution·Ieva BardaJussi Meriluoto
Aug 26, 2004·Ecotoxicology and Environmental Safety·Daniela R de FigueiredoMário J Pereira
Feb 5, 2014·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Marisa FreitasVitor Vasconcelos
Dec 4, 2012·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Daniel Gutiérrez-PraenaAna M Cameán

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.