Bioaccumulation and effects of dietary exposure to the alternative flame retardant, bis(2-ethylhexyl) tetrabromophthalate (TBPH), in the Atlantic killifish, Fundulus heteroclitus

Environmental Toxicology and Chemistry
Diane NacciSaro Jayaraman

Abstract

Bis(2-ethylhexyl) tetrabromophthalate (TBPH), a high production volume flame retardant chemical used as a replacement for banned flame retardants, has been detected in media and human and wildlife tissues globally. We describe bioaccumulation and biological effects from dietary exposure of TBPH to an estuarine fish, Atlantic killifish, Fundulus heteroclitus. Briefly, adult fish were fed carrier control or chemically amended diets for 28 d, followed by 14 d of control diet feeding. Diets were amended with TBPH (TBPH_LO diet, 139 μg/g dry wt, or TBPH_HI diet, 4360 μg/g dry wt) or a polychlorinated biphenyl congener (PCB153 diet, 13 μg/g dry wt), which was included as a positive control for bioaccumulation. Although bioaccumulation of either chemical correlated with fish size, only a small proportion of the TBPH offered (<0.5% total TBPH) had bioaccumulated into TBPH-treated fish by 28 d. In contrast, 24.5% of the PCB153 offered was accounted for in 28-d PCB-treated fish. Although 28-d bioaccumulated concentrations of TBPH differed by sex and treatment, sexes did not differ in their rates of TBPH bioaccumulation, and the time to achieve 50% of 28 d concentration (T1/2 ) was estimated to be 13 d. Depuration rates of TBPH did not di...Continue Reading

References

Oct 16, 2008·Environmental Science & Technology·Heather M StapletonThomas F Webster
Apr 27, 2010·PloS One·Oliana CarnevaliFrancesca Maradonna
Dec 21, 2010·Environment International·Adrian CovaciCynthia A de Wit
Apr 10, 2012·Mutation Research·Jane C Caldwell
May 3, 2012·Environmental Toxicology and Chemistry·David C DepewJames G Wiener
Jul 7, 2012·Environment International·Susan L KlosterhausDenise J Greig
Aug 1, 2012·Environmental Science & Technology·Marie-Line GentesJonathan Verreault
Sep 29, 2012·Environmental Health Perspectives·Sean P McGeeDavid C Volz
Nov 10, 2012·Journal of Biochemical and Molecular Toxicology·Heather B PatisaulHeather M Stapleton
Nov 29, 2012·Environmental Science & Technology·Heather M StapletonArlene Blum
Jan 22, 2013·The Science of the Total Environment·Paula I JohnsonJohn D Meeker
Feb 5, 2013·Toxicological Sciences : an Official Journal of the Society of Toxicology·Sean P McGeeDavid C Volz
Feb 13, 2013·Environmental Toxicology and Chemistry·Benjamin P de JourdanKeith R Solomon
Apr 30, 2013·Environmental Toxicology and Chemistry·Xiaofang WangBingsheng Zhou
Oct 8, 2014·Environmental Science & Technology·Erika D Schreder, Mark J La Guardia
Sep 8, 2015·International Journal of Environmental Research and Public Health·Arjun K Venkatesan, Rolf U Halden
Aug 11, 2016·Toxicology Letters·Darja Gramec SkledarLucija Peterlin Mašič
May 10, 2017·International Journal of Environmental Research and Public Health·Mark J La GuardiaRobert C Hale
Jul 1, 2017·Environment International·Ana CapitãoMiguel M Santos

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