PMID: 8534202Jan 1, 1995Paper

Bioaccumulation of water soluble aluminium chloride in the hippocampus after transdermal uptake in mice

Archives of Toxicology
R AnaneE E Creppy

Abstract

Normally, only very small amounts of ingested aluminium are absorbed and accumulated. Despite the percutaneous absorption of many drugs and chemicals, the skin has not been considered as a possible site at which aluminium could enter the body. Application of low aqueous concentrations of aluminium chloride (A1C1(3), 6H20) (0.025-0.1 micrograms/cm2) to healthy shaved Swiss mouse skin for 130 days led to a significant increase in urine, serum and whole brain aluminium, especially in the hippocampus, compared to control animals. This percutaneous uptake and accumulation of aluminium in the brain was greater than that caused by dietary exposure to 2.3 micrograms per day in feed and water. In vitro studies demonstrated the passage of aluminium through viable mouse skin. This study shows for the first time that aluminium is absorbed through the skin of mice in vivo and this contributes to a greater body burden than does oral uptake.

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Citations

Mar 27, 2001·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·R FlarendS L Hem
Aug 7, 2013·Comptes rendus biologies·Luc KoumolouEdmond E Creppy
Jan 10, 2012·Journal of Applied Toxicology : JAT·André-Pascal SappinoStefano J Mandriota
Mar 9, 2006·Best Practice & Research. Clinical Endocrinology & Metabolism·P D Darbre
Aug 20, 2016·International Journal of Cancer. Journal International Du Cancer·Stefano J MandriotaAndré-Pascal Sappino
Oct 1, 2016·Biological Trace Element Research·Agata Miska-SchrammMałgorzata Kruczek
Jul 28, 2005·Journal of Inorganic Biochemistry·P D Darbre
Apr 1, 2003·Journal of Applied Toxicology : JAT·P D Darbre
Dec 24, 1997·Critical Reviews in Clinical Laboratory Sciences·J L Greger, J E Sutherland
Jan 1, 2004·Toxicology Mechanisms and Methods·Gloria Yiu
Apr 8, 2004·Toxicology and Industrial Health·A BecariaS C Bondy
Nov 26, 2003·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·K G McGrath
Oct 23, 2020·International Journal of Pharmaceutics·Małgorzata TarnowskaMarie-Alexandrine Bolzinger

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