PMID: 6361542Dec 1, 1983Paper

Bioactivation and biotransformation of 1-nitropyrene in liver, lung and nasal tissue of rats

Mutation Research
J A Bond

Abstract

1-Nitropyrene (NP) is a known direct-acting bacterial mutagen and has been detected in the environment from such sources as diesel-exhaust emissions and coal-combustion fly ash. The purpose of this study was to investigate the mutagenic potential of NP in Salmonella typhimurium using rat liver, lung and nasal tissue as the enzyme-activating systems and to measure the rates of NP metabolism in these same tissues. Rat liver, lung and nasal tissue bioactivated NP to mutagens that were detected in the Ames bacterial test system. At all doses of NP and all protein concentrations of tissue S9, mutagenic responses were larger than that observed in the absence of any tissue. In both strains TA98 and TA100, about 1.0 mg/ml liver and nasal tissue S9 appeared to be the optimal concentration which resulted in the largest mutagenic response to NP, whereas 2.0 mg/ml of lung S9 was necessary to yield optimal responses. When NP was incubated with liver, lung or nasal tissue S9 and strain TA98 NR, mutagenic responses were significantly decreased when compared to the response seen in TA98. NP was metabolized to several oxidized metabolites (3-, 6- and 8-hydroxynitropyrene) in all tissues examined. Total rates of formation of NP metabolites for n...Continue Reading

References

Mar 1, 1982·Mutation Research·H S Rosenkranz
Jan 1, 1983·Chemico-biological Interactions·C LuB E McCarry
Apr 1, 1983·Journal of Toxicology and Environmental Health·R L HansonD F Hunt
Jan 29, 1982·Biochemical and Biophysical Research Communications·P C Howard, F A Beland
Jul 15, 1982·Experientia·J P Nachtman, E T Wei
Jul 1, 1981·Mutation Research·R MermelsteinH S Rosenkranz
Jul 1, 1981·Mutation Research·H TokiwaY Ohnishi
Jan 1, 1982·Cancer Letters·E C McCoy, H S Rosenkranz
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Sep 1, 1982·Journal of Toxicology and Environmental Health·T C MarshallA L Brooks
Jul 1, 1981·Toxicology and Applied Pharmacology·D E RickertJ G Dent

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Citations

Dec 31, 1997·Mutation Research·C J Reed
Dec 31, 1997·Mutation Research·J R Thornton-Manning, A R Dahl
Jan 1, 1990·Drug Metabolism Reviews·P P Fu
Apr 25, 2007·Critical Reviews in Toxicology·Douglas McGregor
Sep 30, 1984·Toxicology and Applied Pharmacology·J A BondJ S Dutcher
Oct 1, 1995·The Annals of Otology, Rhinology, and Laryngology·N S KrishnaM L Getchell
May 1, 1993·The Annals of Otology, Rhinology, and Laryngology·M L GetchellT V Getchell
Jan 1, 1991·Critical Reviews in Toxicology·A R Dahl, W M Hadley
Jul 1, 1985·Toxicology and Applied Pharmacology·J A BondR O McClellan

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