PMID: 6361542Dec 1, 1983Paper

Bioactivation and biotransformation of 1-nitropyrene in liver, lung and nasal tissue of rats

Mutation Research
J A Bond


1-Nitropyrene (NP) is a known direct-acting bacterial mutagen and has been detected in the environment from such sources as diesel-exhaust emissions and coal-combustion fly ash. The purpose of this study was to investigate the mutagenic potential of NP in Salmonella typhimurium using rat liver, lung and nasal tissue as the enzyme-activating systems and to measure the rates of NP metabolism in these same tissues. Rat liver, lung and nasal tissue bioactivated NP to mutagens that were detected in the Ames bacterial test system. At all doses of NP and all protein concentrations of tissue S9, mutagenic responses were larger than that observed in the absence of any tissue. In both strains TA98 and TA100, about 1.0 mg/ml liver and nasal tissue S9 appeared to be the optimal concentration which resulted in the largest mutagenic response to NP, whereas 2.0 mg/ml of lung S9 was necessary to yield optimal responses. When NP was incubated with liver, lung or nasal tissue S9 and strain TA98 NR, mutagenic responses were significantly decreased when compared to the response seen in TA98. NP was metabolized to several oxidized metabolites (3-, 6- and 8-hydroxynitropyrene) in all tissues examined. Total rates of formation of NP metabolites for n...Continue Reading


Mar 1, 1982·Mutation Research·H S Rosenkranz
Jan 1, 1983·Chemico-biological Interactions·C LuB E McCarry
Apr 1, 1983·Journal of Toxicology and Environmental Health·R L HansonD F Hunt
Jan 29, 1982·Biochemical and Biophysical Research Communications·P C Howard, F A Beland
Jul 15, 1982·Experientia·J P Nachtman, E T Wei
Jul 1, 1981·Mutation Research·R MermelsteinH S Rosenkranz
Jul 1, 1981·Mutation Research·H TokiwaY Ohnishi
Jan 1, 1982·Cancer Letters·E C McCoy, H S Rosenkranz
Jan 1, 1982·Environmental Mutagenesis·C WeiL S Rosenblatt
Sep 1, 1982·Journal of Toxicology and Environmental Health·T C MarshallA L Brooks
Jul 1, 1981·Toxicology and Applied Pharmacology·D E RickertJ G Dent

❮ Previous
Next ❯


Dec 31, 1997·Mutation Research·C J Reed
Dec 31, 1997·Mutation Research·J R Thornton-Manning, A R Dahl
Jan 1, 1990·Drug Metabolism Reviews·P P Fu
Apr 25, 2007·Critical Reviews in Toxicology·Douglas McGregor
Sep 30, 1984·Toxicology and Applied Pharmacology·J A BondJ S Dutcher
Oct 1, 1995·The Annals of Otology, Rhinology, and Laryngology·N S KrishnaM L Getchell
May 1, 1993·The Annals of Otology, Rhinology, and Laryngology·M L GetchellT V Getchell
Jan 1, 1991·Critical Reviews in Toxicology·A R Dahl, W M Hadley
Jul 1, 1985·Toxicology and Applied Pharmacology·J A BondR O McClellan

❮ Previous
Next ❯

Related Concepts

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.


Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.


Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.