PMID: 2488247Jan 1, 1989Paper

Bioactivation of xenobiotics by cytochrome P-448 and its role in the process of carcinogenesis

Postȩpy higieny i medycyny doświadczalnej
W Lutz, W Sułkowski

Abstract

The paper presents the general data concerning cytochrome P-448, as well as its participation in the formation of oxygen radicals and active metabolic intermediates, originated during xenobiotics' oxidation. Also, induction of synthesis of cytochrome P-448 (aromatic hydrocarbons hydroxylase), along with the role this phenomenon plays in the initiation of neoplastic process, are discussed.

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