Bioactive 3,8-Epoxy Iridoids from Valeriana jatamansi

Chemistry & Biodiversity
Li-Qiu QuanHong-Mei Li

Abstract

Twelve 3,8-epoxy iridoids, including four new compounds, jatamanins R-U (1-4), and eight known compounds (5-12), were obtained from the roots and rhizomes of Valeriana jatamansi. The structures were elucidated from analysis of spectroscopic data. The absolute configurations of 1-4 were determined by comparison of experimental and literature ECD spectra. Moreover, the compounds were evaluated for cytotoxic effects against glioma stem cells, inhibition of NO production, activity against influenza A virus and reversal of multidrug resistance of HepG2/ADR cells. Compounds 9 and 12 showed significant cytotoxic potency against GSC-18# (IC50 =1.351 and 4.439 μg ml-1 , respectively) and GSC-3# (IC50 =10.88 and 6.348 μg ml-1 , respectively) glioma stem cells, while compound 12 was also slightly less potent against GSC-12# (IC50 =13.45 μg ml-1 ) glioma stem cell growth. In addition, compounds 9 and 12 displayed obvious inhibition of NO production (IC50 =4.6 and 15.8 μm, respectively).

References

Sep 25, 2002·Bioorganic & Medicinal Chemistry Letters·Nobutoshi MurakamiMotomasa Kobayashi
Nov 8, 2003·Journal of Asian Natural Products Research·Yu-Ping TangBiao Yu
Jan 31, 2004·Pharmacology, Biochemistry, and Behavior·Sebastián FernándezMariel Marder
Nov 10, 2005·Archives of Pharmacal Research·Ye-Gao ChenShi-Hong Gui
Dec 29, 2006·Chemistry & Biodiversity·Chandra S MathelaSiddharth Pandey
Dec 29, 2006·Chemistry & Biodiversity·Xiu-Ping YangZhong-Jian Jia
Feb 16, 2010·Journal of Natural Products·Sheng LinHui Wang
Apr 30, 2010·The British Journal of Dermatology·S-W HuangJ-J Shieh
Oct 19, 2011·Chemistry & Biodiversity·Ram S VermaHemendra P Singh
Oct 6, 2012·Phytochemistry·Sheng LinWei-dong Zhang
Mar 14, 2014·Liver International : Official Journal of the International Association for the Study of the Liver·Qing-Feng XiangChang-Zhen Shang
Aug 26, 2014·ACS Medicinal Chemistry Letters·Zhao DangChin-Ho Chen
Feb 11, 2015·Fitoterapia·Fa-Wu DongJiang-Miao Hu
May 15, 2015·Journal of Asian Natural Products Research·Sheng LinWei-Dong Zhang
Dec 8, 2016·Journal of Asian Natural Products Research·Sheng LinWei-Dong Zhang
Mar 16, 2017·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Bo YangHuajun Zhao
Jun 18, 2017·Phytochemistry·Ru-Jing WangYu-Zhu Tan
Mar 1, 2018·Bioorganic & Medicinal Chemistry·Xin WeiXiao-Dong Luo

❮ Previous
Next ❯

Citations

Dec 3, 2020·Natural Product Research·Li-Qiu QuanHong-Mei Li
Dec 11, 2020·Natural Product Research·Antim K MauryaVijai K Agnihotri

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.