Jul 23, 2015

Bioactive 7-Oxabicyclic[6.3.0]lactam and 12-Membered Macrolides from a Gorgonian-Derived Cladosporium sp. Fungus

Marine Drugs
Fei CaoChang-Yun Wang

Abstract

One new bicyclic lactam, cladosporilactam A (1), and six known 12-membered macrolides (2-7) were isolated from a gorgonian-derived Cladosporium sp. fungus collected from the South China Sea. Their complete structural assignments were elucidated by comprehensive spectroscopic investigation. Quantum chemistry calculations were used in support of the structural determination of 1. The absolute configuration of 1 was determined by calculation of its optical rotation. Cladosporilactam A (1) was the first example of 7-oxabicyclic[6.3.0]lactam obtained from a natural source. Compound 1 exhibited promising cytotoxic activity against cervical cancer HeLa cell line with an IC50 value of 0.76 μM.

Mentioned in this Paper

In Vivo NMR Spectroscopy
Antineoplastic Agents
MAP2K7 protein, human
Coral
Aquatic Organisms
Cladosporilactam A
Macrolide Antibiotics
Cladosporium sp
Determination Aspects
Partial Wave Spectroscopic Microscopy

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