Jul 24, 2012

Bioactive aldehyde-modified phosphatidylethanolamines

Lilu Guo, Sean S Davies


Lipid peroxidation generates a variety of lipid aldehydes, which have been recognized to modify protein and DNA, causing inflammation and cancer. However, recent studies demonstrate that phosphatidylethanolamine (PE) is a major target for these aldehydes, forming aldehyde-modified PEs (al-PEs) as a novel family of mediators for inflammation. This review summarizes our current understanding of these al-PEs, including formation, detection, structural characterization, physiological relevance and mechanism of action.

Mentioned in this Paper

Biochemical Pathway
Docosahexaenoic acid
Systemic Inflammatory Response Syndrome
Post-Translational Protein Processing
Chronic Disease
Fuchs Endothelial Dystrophy

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