Bioactive asterric acid derivatives from the Antarctic ascomycete fungus Geomyces sp

Journal of Natural Products
Yan LiYongsheng Che

Abstract

Five new asterric acid derivatives, ethyl asterrate (3), n-butyl asterrate (4), and geomycins A-C (6-8), have been isolated from cultures of an isolate of the Antarctic ascomycete fungus Geomyces sp. The structures of these metabolites were elucidated by NMR spectroscopy. The absolute configuration of 8 was determined by application of the CD excitation chirality method. Compound 7 displayed antifungal activity against Aspergillus fumigatus, whereas 8 showed antimicrobial activities against gram-positive and gram-negative bacteria.

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Citations

Jun 18, 2010·Antonie van Leeuwenhoek·Nazia MojibAsim K Bej
Jul 5, 2013·Journal of Asian Natural Products Research·Chun-Chi FengHao Gao
Apr 9, 2013·New Biotechnology·Patrick M MurrayDaniel J Walsh
May 5, 2016·Extremophiles : Life Under Extreme Conditions·Zhuang DingTianjiao Zhu
Nov 24, 2019·Extremophiles : Life Under Extreme Conditions·Mayara B OgakiLuiz H Rosa
Mar 1, 2017·Marine Drugs·Yuan TianFeng-Chun Zhao
Feb 6, 2020·Applied Microbiology and Biotechnology·Muhammad IbrarFariha Hasan
Jun 6, 2018·Marine Drugs·Xuan ZhangChang-Qi Zhao
Jun 14, 2020·Extremophiles : Life Under Extreme Conditions·Mayara B OgakiLuiz H Rosa
Sep 10, 2020·International Journal of Environmental Research and Public Health·Laura ZucconiSolveig Tosi
Apr 23, 2010·Journal of Natural Products·Jie LinYongsheng Che
Apr 25, 2021·Journal of Asian Natural Products Research·Hao-Bing YuXiao-Yu Liu
Jun 3, 2021·Journal of Fungi·Stefano VarrellaCinzia Corinaldesi
Jul 14, 2021·The Journal of Antibiotics·Zhe GuoLing Liu
Mar 4, 2015·Journal of Natural Products·Luis FigueroaInmaculada Vaca

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