Bioactive azafluorenone alkaloids from Polyalthia debilis (Pierre) Finet & Gagnep.

Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry
Supaluk PrachayasittikulVirapong Prachayasittikul

Abstract

This study investigated bioactive extracts of Polyalthia debilis (Annonaceae) with antimicrobial, antimalarial and cytotoxic activities. Extensive chromatographic isolations provided azafluorenone alkaloids; onychine (1) and 7-methoxyonychine (2) together with a mixture of beta-sitosterol and stigmasterol. The two alkaloids were isolated from the P. debilis for the first time. Isolated fractions containing a mixture of triterpenoids (C7, C8 and C9) exhibited the most potent antimicrobial activity against many bacterial strains with minimum inhibitory concentration of 64 microg/mL. Fractions with antimalarial and cytotoxic activities were also observed. The findings suggest the potential use of P. debilis in medicinal applications.

Citations

Feb 28, 2020·Current Organic Synthesis·Claudia R B GomesVictor Facchinetti
Oct 31, 2017·Evidence-based Complementary and Alternative Medicine : ECAM·Shuaibu Babaji SanusiMuhammad Murtala Mainasara
Nov 8, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Renzo Rossi, Maurizio Ciofalo
Oct 23, 2010·Journal of Natural Products·George A Kraus, Aaron Kempema

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Methods Mentioned

BETA
column chromatography

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