Bioactive Azepine-Indole Alkaloids from Psychotria nemorosa.

Journal of Natural Products
Luiz C Klein-JúniorAmélia Henriques

Abstract

Phytochemical investigation of the alkaloid extract of the aerial parts of Psychotria nemorosa led to the isolation and characterization of 10 azepine-indole alkaloids, i.e., cimitrypazepine (1), fargesine (2), nemorosines A (3), and B (12), nemorosinosides A-F (4-9), as well as two β-carboline derivatives, 10-hydroxyisodolichantoside (10) and 10-hydroxydolichantoside (11), an isoxazole alkaloid, nemorosinoside G (13), serotonin (14), bufotenine (15), and (S)-gentianol (16). Compounds 3-13 have not yet been described. These compounds were isolated by semipreparative HPLC, and their structures were determined by means of HRMS, NMR, and ECD measurements. In addition, the monoamine oxidase-A (MAO-A), MAO-B, acetylcholinesterase (AChE), and butyrylcholinesterase (BChE) inhibitory activities were evaluated. Alkaloids 1-3 inhibited the MAO-A activity with IC50 values of 1.4, 1.4, and 0.9 μM, respectively.

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Nov 10, 2017·Journal of Natural Products·Luiz C Klein-JúniorAmélia T Henriques
Feb 8, 2018·Redox Biology·James Nathan CobleyDamian Miles Bailey

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Citations

Jan 24, 2021·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Juliana M LimaQuezia B Cass
Jan 21, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Tomasz Tuzimski, Anna Petruczynik

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