Bioactive Compounds from Marine Organisms: Potential for Bone Growth and Healing

Marine Drugs
Matthew A Carson, Susan A Clarke

Abstract

Marine organisms represent a highly diverse reserve of bioactives which could aid in the treatment of a wide range of diseases, including various musculoskeletal conditions. Osteoporosis in particular would benefit from a novel and effective marine-based treatment, due to its large disease burden and the inefficiencies of current treatment options. Osteogenic bioactives have been isolated from many marine organisms, including nacre powder derived from molluscan shells and fucoidan-the sulphated polysaccharide commonly sourced from brown macroalgae. Such extracts and compounds are known to have a range of osteogenic effects, including stimulation of osteoblast activity and mineralisation, as well as suppression of osteoclast resorption. This review describes currently known soluble osteogenic extracts and compounds from marine invertebrates and algae, and assesses their preclinical potential.

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Citations

Mar 25, 2019·Expert Opinion on Therapeutic Patents·Pravin ShindeAnita Mandhare
Mar 4, 2020·Marine Drugs·Nuri GuevenJ Helen Fitton
Jun 4, 2020·Marine Drugs·Adrian Florian BălașaAlexandru Mihai Grumezescu
Oct 24, 2020·Critical Reviews in Food Science and Nutrition·Yixuan ChenJiajin Zhu
Dec 2, 2020·Marine Drugs·Yuliya KhrunykHermann Ehrlich
Jan 13, 2021·BMC Complementary Medicine and Therapies·Xiaohan ChenJinju Jiang
Oct 11, 2020·Biochimica Et Biophysica Acta. General Subjects·Gan QiaoXiukun Lin
May 1, 2021·Marine Drugs·Disha VarijakzhanChou-Min Chong
May 1, 2021·Materials·Cristina ChircovAlexandru Mihai Grumezescu
Nov 19, 2021·Journal of Biomedical Materials Research. Part a·Mads Suhr NielsenMing Ding

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