Bioactive compounds of Crocus sativus L. and their semi-synthetic derivatives as promising anti-Helicobacter pylori, anti-malarial and anti-leishmanial agents

Journal of Enzyme Inhibition and Medicinal Chemistry
Celeste De MonteFrancesca Sisto

Abstract

Crocus sativus L. is known in herbal medicine for the various pharmacological effects of its components, but no data are found in literature about its biological properties toward Helicobacter pylori, Plasmodium spp. and Leishmania spp. In this work, the potential anti-bacterial and anti-parasitic effects of crocin and safranal, two important bioactive components in C. sativus, were explored, and also some semi-synthetic derivatives of safranal were tested in order to establish which modifications in the chemical structure could improve the biological activity. According to our promising results, we virtually screened our compounds by means of molecular modeling studies against the main H. pylori enzymes in order to unravel their putative mechanism of action.

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Citations

Mar 18, 2016·Journal of Enzyme Inhibition and Medicinal Chemistry·Maria Concetta GidaroSimone Carradori
May 11, 2016·Journal of Enzyme Inhibition and Medicinal Chemistry·Simone CarradoriLetizia Angiolella
May 28, 2016·Journal of Enzyme Inhibition and Medicinal Chemistry·Nimet BaltasSevgi Kolayli
Feb 6, 2017·Bioorganic & Medicinal Chemistry·Alane B VermelhoClaudiu T Supuran
Feb 14, 2020·Biomolecules·Larissa Lucena PéricoClélia Akiko Hiruma-Lima
Feb 7, 2020·Pharmaceuticals·Micheline DrayeRomain Duwald
May 29, 2021·Journal of Biochemical and Molecular Toxicology·Luiz Roberto Carraro JuniorCristiani Folharini Bortolatto
Jul 5, 2021·European Journal of Medicinal Chemistry·Elham GhobadiSaeed Emami
Jul 15, 2021·Parasites & Vectors·Chuanchuan LiuLan Ma
Aug 27, 2021·Journal of Ethnopharmacology·Bingcong XingQingsong Shao

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