PMID: 18716164Aug 22, 2008Paper

Bioactive dietary polyphenolic compounds reduce nonheme iron transport across human intestinal cell monolayers

The Journal of Nutrition
Eun-Young KimOkhee Han

Abstract

There is persuasive epidemiological evidence that regular intake of dietary bioactive polyphenolic compounds promotes human health. Because dietary polyphenolic compounds have a wide range of effects in vivo and vitro, including chelation of metals such as iron, it is prudent to test whether the regular consumption of bioactive polyphenolic components impair the utilization of dietary iron. We examined the influence of the dietary polyphenols (-) -epigallocatechin-3-gallate (EGCG) and grape seed extract (GSE) on transepithelial iron transport in Caco-2 intestinal cells. The range of EGCG and GSE concentrations used in this study was within physiological levels and did not affect the integrity of differentiated Caco-2 cell monolayers. Both EGCG and GSE decreased (P < 0.001) transepithelial iron transport. However, apical iron uptake was increased (P < 0.001) by the addition of EGCG and GSE. The increased uptake of iron might be due in part to the reducing activity of EGCG and GSE. Both EGCG and GSE reduced approximately 15% of the applied Fe(3+) to Fe(2+) in the uptake buffer. Despite the increased cellular levels of (55)Fe, the transfer of iron across the basolateral membrane of the enterocyte was extremely low, indicating that...Continue Reading

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Citations

Oct 9, 2013·BioMed Research International·Naushad Ali ToolseeTheeshan Bahorun
May 23, 2014·Frontiers in Neurology·Yue-Qin ZengXin-Fu Zhou
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