Bioactive diphenyl ether derivatives from a gorgonian-derived fungus Talaromyces sp

Chemistry & Biodiversity
Min ChenChang-Yun Wang

Abstract

Three new diphenyl ether derivatives, talaromycins A-C (1-3, resp.), together with six known analogs, 4-9, were isolated from a gorgonian-derived fungus, Talaromyces sp. The structures of the new compounds were determined by analysis of extensive NMR spectroscopic data. All of the isolated metabolites, 1-9, were evaluated for their cytotoxic and antifouling activities. Compound 4 exhibited pronounced cytotoxicity against the tested human cell lines with the IC50 values ranging from 4.3 to 9.8 μM. Compounds 3, 5, 8, and 9 showed potent antifouling activities against the larval settlement of the barnacle Balanus amphitrite with the EC50 values ranging from 2.2 to 4.8 μg/ml.

References

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Citations

Feb 24, 2016·Marine Drugs·Rosario Nicoletti, Antonio Trincone
Jan 28, 2016·Natural Product Research·Xiao-Song XieShao-Hua Wu
Mar 16, 2017·Natural Product Reports·John W BluntMichèle R Prinsep
Jan 16, 2020·International Journal of Environmental Research and Public Health·Sharon PeloEzekiel Green
Jun 11, 2018·World Journal of Microbiology & Biotechnology·Xiao-Yong ZhangJie Bao
Apr 20, 2021·Heliyon·Esraa Ahmed Mohamed El-BondklyAya Ahmed Mohamed El-Bondkly

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