Bioactive Diterpenoids from Clerodendrum kiangsiense

Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry
Ming-Feng XuLu'e Shi

Abstract

A new abeo-abietane diterpenoid, 12-methoxy-6,11,14,16-tetrahydroxy-17(15→16)-abeo-5,8,11,13-abietatetraen-3,7-dione (8), was isolated from the hydroalcoholic extract of the herb of Clerodendrum kiangsiense along with seven known diterpenoids (1-7). Their structures were identified on the basis of spectroscopic analyses including two-dimensional NMR and comparison with literature data. All of these compounds were evaluated for their cytotoxic activities against the growth of human cancer cells lines HL-60, SMMC-7721, A-549 and MCF-7 by the MTT assay. The results showed that cryptojaponol (4), fortunin E (6) and 8 exhibited significant cytotoxicity against four human cancer cell lines.

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Citations

Apr 4, 2017·Phytotherapy Research : PTR·Muhammad Torequl Islam
Sep 7, 2017·Natural Product Reports·James R Hanson
May 11, 2018·Advances in Neonatal Care : Official Journal of the National Association of Neonatal Nurses·Samantha Alessi

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Methods Mentioned

BETA
NMR
column chromatography

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