Bioactive endophytic fungi isolated from Caesalpinia echinata Lam. (Brazilwood) and identification of beauvericin as a trypanocidal metabolite from Fusarium sp

Memórias do Instituto Oswaldo Cruz
Fernanda Fraga CamposB B Cota

Abstract

Aiming to identify new sources of bioactive secondary metabolites, we isolated 82 endophytic fungi from stems and barks of the native Brazilian tree Caesalpinia echinata Lam. (Fabaceae). We tested their ethyl acetate extracts in several in vitro assays. The organic extracts from three isolates showed antibacterial activity against Staphylococcus aureus and Escherichia coli [minimal inhibitory concentration (MIC) 32-64 μg/mL]. One isolate inhibited the growth of Salmonella typhimurium (MIC 64 μg/mL) and two isolates inhibited the growth of Klebsiella oxytoca (MIC 64 μg/mL), Candida albicans and Candida tropicalis (MIC 64-128 μg/mL). Fourteen extracts at a concentration of 20 μg/mL showed antitumour activities against human breast cancer and human renal cancer cells, while two isolates showed anti-tumour activities against human melanoma cancer cells. Six extracts were able to reduce the proliferation of human peripheral blood mononuclear cells, indicating some degree of selective toxicity. Four isolates were able to inhibit Leishmania (Leishmania) amazonensis and one isolate inhibited Trypanosoma cruzi by at least 40% at 20 μg/mL. The trypanocidal extract obtained from Fusarium sp. [KF611679] culture was subjected to bioguided f...Continue Reading

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Citations

Mar 1, 2017·World Journal of Microbiology & Biotechnology·Igor Pereira da SilvaMarcos Antônio Soares
Sep 29, 2018·Mini Reviews in Medicinal Chemistry·Qinghua WuKamil Kuca
May 12, 2018·Applied Microbiology and Biotechnology·Juliana LenziLorena Benathar Ballod Tavares
Apr 17, 2020·Journal of Applied Microbiology·Valéria Macedo CardosoCristiane Fernanda Fuzer Grael
Dec 14, 2017·Memórias do Instituto Oswaldo Cruz·Betania Barros CotaCarlos Leomar Zani
Oct 28, 2020·Current Microbiology·Bruno A RibeiroEliane O Silva
Jan 8, 2021·Parasitology Research·Jean Baptiste Hzounda FokouFabrice Fekam Boyom
Apr 4, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Manuel Jesús Chan-BacabBenjamín Otto Ortega-Morales
Jul 3, 2021·Journal of Fungi·Rafael Dorighello CadamuroGislaine Fongaro
Jun 25, 2020·Mini Reviews in Medicinal Chemistry·Maria Beatriz Silva Costa, Camila Martins de Oliveira

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Methods Mentioned

BETA
nuclear magnetic resonance
NMR

Software Mentioned

BLAST
SciFinder
PHRAP
PHRED
BLASTN
LCsolution

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