Bioactive food and exercise in chronic kidney disease: Targeting the mitochondria

European Journal of Clinical Investigation
Denise MafraFerdinand von Walden

Abstract

Chronic kidney disease (CKD), which affects 10%-15% of the population, associates with a range of complications-such as cardiovascular disease, frailty, infections, muscle and bone disorders and premature ageing-that could be related to alterations of mitochondrial number, distribution, structure and function. As mitochondrial biogenesis, bioenergetics and the dynamic mitochondrial networks directly or indirectly regulate numerous intra- and extracellular functions, the mitochondria have emerged as an important target for interventions aiming at preventing or improving the treatment of complications in CKD. In this review, we discuss the possible role of bioactive food compounds and exercise in the modulation of the disturbed mitochondrial function in a uraemic milieu.

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Citations

Nov 14, 2019·Critical Reviews in Food Science and Nutrition·Vidmantas BendokasJulius Liobikas
Nov 15, 2019·Current Opinion in Nephrology and Hypertension·Adamasco CupistiMaurizio Gallieni
Sep 24, 2020·Nature Reviews. Nephrology·Denise MafraPeter Stenvinkel
Sep 16, 2020·Journal of Clinical Medicine·Ahmad AgilGumersindo Fernández-Vázquez
Aug 23, 2019·American Journal of Physiology. Renal Physiology·Chang LiuFerdinand von Walden
Jan 19, 2021·Oxidative Medicine and Cellular Longevity·Iwona KwiatkowskaDariusz Pawlak
May 18, 2021·The Journal of Nutritional Biochemistry·Sarai Vásquez-ReyesArmando R Tovar

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