Bioactive glass S53P4 as bone graft substitute in treatment of osteomyelitis

Bone
Nina LindforsJ Salo

Abstract

Bioactive glass (BAG)-S53P4 is an osteoconductive bone substitute with proven antibacterial and bone bonding properties. In a multicentre study 11 patients with verified chronic osteomyelitis in the lower extremity and the spine were treated with BAG-S53P4 as a bone substitute. The cavitary bone defect and the surrounding of a spinal implant were filled with BAG-S53P4. The most common pathogen causing the infection was Staphylococcus aureus. The mean follow-up was 24 months (range 10-38). BAG-S53P4 was well tolerated. Nine patients healed without complications. One patient who achieved good bone formation sustained a superficial wound infection due to vascular problems in the muscle flap, and one patient had an infection due to a deep haematoma. This study shows that BAG-S53P4 is a good and well-tolerated bone substitute, and can be used in treatment of osteomyelitis with good primary results.

References

Jan 1, 1988·Annals of the New York Academy of Sciences·L L Hench
Jan 1, 1973·Journal of Biomedical Materials Research·L L Hench, H A Paschall
Nov 9, 1984·Science·L L Hench, J Wilson
Aug 4, 1998·Acta Odontologica Scandinavica·P StoorJ I Salonen
Dec 17, 1998·Acta Orthopaedica Scandinavica·G H WalenkampM de Leeuw
Sep 17, 2005·Journal of Materials Science. Materials in Medicine·D Boyd, M R Towler
Jun 15, 2007·Journal of Materials Science. Materials in Medicine·Eveliina MunukkaErkki Eerola
Jul 11, 2007·Journal of Materials Science. Materials in Medicine·Outi LeppärantaErkki Eerola
Feb 5, 2008·Diabetes & Metabolism·A Hartemann-Heurtier, E Senneville
Feb 13, 2009·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·A W WrenM R Towler
Jun 24, 2009·Journal of Controlled Release : Official Journal of the Controlled Release Society·Zongping XieJianqiang Wang
Jun 5, 2010·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Nina C LindforsAllan J Aho

❮ Previous
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Citations

Mar 29, 2014·Journal of the Mechanical Behavior of Biomedical Materials·S López-EstebanJ S Moya
Jun 25, 2014·Future Microbiology·Lorenzo DragoCarlo Luca Romanò
Jun 9, 2014·Materials Science & Engineering. C, Materials for Biological Applications·Mohamed N RahamanWenhai Huang
Mar 25, 2014·Dental Materials : Official Publication of the Academy of Dental Materials·Onur OralPekka K Vallittu
Feb 11, 2014·International Journal of Oral and Maxillofacial Surgery·N ChanchareonsookJ A Jansen
Aug 29, 2012·Dental Materials : Official Publication of the Academy of Dental Materials·Sara NgangaLeena Hupa
Aug 28, 2012·Acta Biomaterialia·Julian R Jones
Apr 11, 2015·Colloids and Surfaces. B, Biointerfaces·Kai ZhengAldo R Boccaccini
Nov 26, 2015·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Se Heang OhJin Ho Lee
Oct 16, 2015·The Journal of Antimicrobial Chemotherapy·Monica BortolinLorenzo Drago
Dec 10, 2015·Frontiers in Bioengineering and Biotechnology·Larry L Hench, Julian R Jones
Jun 3, 2015·Advanced Drug Delivery Reviews·Haibo QuPaul Ducheyne
May 29, 2015·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Putzer DavidNogler Michael
Jan 10, 2016·Injury·Jean-Charles Aurégan, Thierry Bégué
Oct 11, 2013·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Débora C Coraça-HuberMichael Nogler
Dec 21, 2013·Journal of Biomedical Materials Research. Part a·Rainer DetschAldo R Boccaccini
Apr 26, 2013·Head & Neck·Kalle M J AitasaloPekka K Vallittu
Oct 20, 2015·Materials Science & Engineering. C, Materials for Biological Applications·Furqan A Shah
Aug 4, 2015·Acta Biomaterialia·Julian R Jones
Jun 24, 2015·Journal of Materials Science. Materials in Medicine·J MasseraL Hupa
Feb 15, 2015·World Neurosurgery·Jaakko M PiitulainenJussi P Posti
Dec 3, 2014·Acta Biomaterialia·Valentina Miguez-PachecoAldo R Boccaccini
Oct 1, 2016·Bio-medical Materials and Engineering·Jussi SarinPekka K Vallittu
Dec 31, 2016·Journal of Applied Microbiology·J Rivadeneira, A Gorustovich
Mar 15, 2012·Scandinavian Journal of Surgery : SJS : Official Organ for the Finnish Surgical Society and the Scandinavian Surgical Society·J RantakokkoN C Lindfors
May 26, 2017·The Journal of Craniofacial Surgery·Patricia StoorRisto Kontio
Sep 28, 2012·The Annals of Otology, Rhinology, and Laryngology·Jussi SarinJaakko Pulkkinen
Mar 1, 2012·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Juha Tapio Silvola
Jul 1, 2017·Tropical Medicine & International Health : TM & IH·J GeurtsP Moh
Oct 5, 2017·Journal of Biomedical Materials Research. Part a·Muhammad RizwanMohd Hamdi

❮ Previous
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