Bioactive hydroxypropionylated glucose derivatives from Astragalus bhotanensis.

Natural Product Research
Lin QiuBei Jiang

Abstract

Four previously undescribed hydroxypropionylated d-glucose derivatives, astrabhotins A-D (1-4), along with ten known compounds α-d-glucose (5), β-d-glucose (6), quebrachitol (7), 3-hydroxypropionic acid (8), oleic acid (9), isoliquiritigenin (10), liquiritigenin (11), odoratin (12), 7β-hydroxysitosterol (13) and daucosterol (14), were isolated from the roots of Astragalus bhotanensis. Their structures were elucidated based on the analyses of extensive spectroscopic data and physicochemical properties. Astrabhotin A (1) reduced the writhing response remarkably with 52.5% inhibition by acetic acid induced writhing test. The analgesic effect of 1 was stronger than the standard drug aspirin. In addition, compounds 1 and 3 showed significant antioxidant activities with IC50 values of 9.9 ± 0.2 and 7.9 ± 0.4 μg/mL, and exhibited weak or moderate cytotoxicity against HepG2 cells with IC50 values of 106.6 ± 2.7 and 42.0 ± 0.9 μg/mL, respectively.[Figure: see text].

References

Mar 7, 2000·Phytochemistry·A PauloP J Houghton
Dec 14, 2004·Phytochemistry·Michael SchwarzHeidrun Anke
Jun 30, 2005·Magnetic Resonance in Chemistry : MRC·Anatoli P SobolevAnna L Segre
Aug 22, 2008·Carbohydrate Research·Martina DíazCarmen Rossini
Mar 12, 2013·Biotechnology Advances·Vinod KumarSunghoon Park
Jun 19, 2013·Chemistry & Biodiversity·Li-Peng YangJian-Qin Jiang
Nov 6, 2014·Planta medica·Chao-Jiang XiaoBei Jiang
Nov 14, 2014·Journal of Asian Natural Products Research·Chao-Jiang XiaoBei Jiang
Nov 20, 2014·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Xiaoxia LiTao Wang
Jan 7, 2017·BMC Complementary and Alternative Medicine·Jing-Wen ZhaoLi Lin
Apr 17, 2019·Natural Product Research·Jin-Qiang LiBei Jiang
May 3, 2019·Journal of Asian Natural Products Research·Ming-Zao ZhaoBei Jiang
Jul 31, 2019·Natural Product Research·Ding-Wei WangBei Jiang

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Citations

Oct 28, 2021·Natural Product Research·Xiu-Rong WuBei Jiang

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Methods Mentioned

BETA
NMR

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