Bioactive isopimarane diterpenes from the fungus, Epicoccum sp. HS-1, associated with Apostichopus japonicus

Marine Drugs
Xue-Kui XiaZhigang She

Abstract

One new isopimarane diterpene (1), together with two known compounds, 11-deoxydiaporthein A (2) and iso-pimara-8(14),15-diene (3) were isolated from the culture of Epicoccum sp., which was associated with Apostichopus japonicus. Their structures were determined by the analysis of 1D and 2D NMR, as well as mass spectroscopic data. The absolute configuration of Compound 1 was deduced by a single-crystal X-ray diffraction experiment using CuKα radiation. In the bioactivity assay, both Compounds 1 and 2 exhibited α-glucosidase inhibitory activity with IC50 values of 4.6 ± 0.1 and 11.9 ± 0.4 μM, respectively. This was the first report on isopimarane diterpenes with α-glucosidase inhibitory activity.

References

Mar 27, 2003·Bioorganic & Medicinal Chemistry Letters·Suppamit DettrakulYodhathai Thebtaranonth
Jan 3, 2006·European Journal of Medicinal Chemistry·Zhi-yun DuAlbert S C Chan
Mar 16, 2012·Bioorganic & Medicinal Chemistry Letters·Xuekui XiaYongcheng Lin
Dec 25, 2012·Natural Product Reports·John W BluntMichèle R Prinsep
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Citations

Jul 25, 2017·Chemistry & Biodiversity·Xiaoli WangXiaoyu Liu
Jun 24, 2020·Marine Drugs·Minghua JiangSenhua Chen
Oct 30, 2018·Critical Reviews in Microbiology·Raíssa Mesquita BragaWelington Luiz Araújo
Mar 16, 2017·Natural Product Reports·John W BluntMichèle R Prinsep
Jan 23, 2018·Frontiers in Microbiology·Sunil K DeshmukhNihar Ranjan

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Methods Mentioned

BETA
NMR
X-ray

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