Bioactive labdane diterpenoids from Renealmia alpinia collected in the Suriname rainforest

Journal of Natural Products
B N ZhouDavid G I Kingston

Abstract

The preservation of tropical rainforests is an important goal both for the intrinsic value of their cultural and biological diversity as well as for the well-being of the peoples who make these forests their home. In addition, tropical forests are potential sources of new pharmaceutical products that can only be found by chemical prospecting in Nature's genetically encoded combinatorial library. As part of an effort to integrate biodiversity conservation and drug discovery with economic development, we have initiated a collaborative program to discover potential pharmaceuticals in the rainforest of Suriname. The plant Renealmia alpinia (Zingiberaceae) was selected for investigation based on its ethnomedical use as a febrifuge, but testing in the yeast Sc-7 assay gave a positive response, indicative of cytotoxic activity. Using this bioassay, the two new labdane diterpense, 11-hydroxy-8(17),12(E)-labdadien-15,-16-dial 11,15-hemiacetal (1) and 16-oxo-8(17),12(E)-labdadien-15-oic acid (2), and the known diterpene, 8(17),12(E)-labdadien-15,16-dial (3), have been isolated. Their structures were elucidated by 1D and 2D NMR techniques (DEPT, COSY, HETCOR, HMBC, and NOESY) and IR, UV, and MS spectra, and the absolute stereochemistry of...Continue Reading

References

Apr 1, 1988·Planta medica·H Morita, H Itokawa

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Citations

Jun 29, 1999·Current Opinion in Microbiology·G M Garrity, J Hunter-Cevera
Sep 25, 2014·Journal of Ethnopharmacology·Billy Joel CabanillasNicolas Fabre
Jun 9, 2009·Journal of Ethnopharmacology·Mariana Laundry de MesquitaLaila Salmen Espindola
Feb 12, 2009·Mycoses·Fernanda Melo e SilvaLaila Salmen Espindola
Nov 23, 2006·Steroids·Jianqin JiangFengchang Lou
Jun 2, 2015·Journal of Ethnopharmacology·Bradley C Bennett, Rocío Alarcón
May 1, 2012·Food Chemistry·Zhi-Heng HePaul Pui-Hay But
Oct 15, 2014·Asian Pacific Journal of Tropical Medicine·Isabel Gómez-Betancur, Dora Benjumea
Dec 12, 2001·BMC Complementary and Alternative Medicine·C LansE Bridgewater
Mar 15, 2015·Chemistry & Biodiversity·Qiang-Ming LiLing-Yi Kong
Apr 18, 2019·Anais Da Academia Brasileira De Ciências·Kathlyn V GevúMaura DA Cunha

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