Bioactive Limonoid Constituents of Munronia henryi

Journal of Natural Products
Ying YanXiao-jiang Hao

Abstract

Fourteen new limonoids, munronins A-N (1-14), and eight known limonoids (15-22) were isolated from the whole plants of Munronia henryi. The structures of the new compounds were elucidated by 2D NMR spectroscopy and mass spectrometry, and the structure of 8 was confirmed by single-crystal X-ray diffraction analysis. Compound 1 represents the first limonoid found with a novel 7-oxabicyclo[2.2.1]heptane moiety produced by incorporating C-11 and C-14 via an oxygen atom. All compounds were evaluated for their anti-tobacco mosaic virus (TMV) activity and in vitro cytotoxicity against the human cancer HL-60, SMMC-7721, A-549, MCF-7, and SW-480 cell lines. Among them, compounds 2, 8, 9, 10, 11, 12, 18, and 20 showed significant anti-TMV activity, with IC50 values in the range 19.6-44.4 μg/mL. Compounds 1 and 18 exhibited cytotoxic effects for all five cancer cell lines, with IC50 values between 0.4 and 4.8 μM.

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Citations

Mar 12, 2016·Journal of Natural Products·Xiao-Hui LiXiao-Jiang Hao
Mar 21, 2018·Natural Products and Bioprospecting·Yuan-Liang MaXiao-Jiang Hao
Feb 15, 2020·Natural Product Reports·Robert A Hill, Joseph D Connolly
Jul 23, 2018·Natural Products and Bioprospecting·Yue-Mao Shen, Duo-Zhi Chen
Aug 18, 2018·Acta Crystallographica. Section E, Crystallographic Communications·Patrice Kenfack TsobnangIgnas Tonlé Kenfack
Sep 24, 2019·Journal of Asian Natural Products Research·SeonJu ParkSeung Hyun Kim
Sep 22, 2020·Science China. Life Sciences·Yuemao Shen, Xiaojiang Hao
Apr 5, 2018·Frontiers in Chemistry·Haishan LiuWeiming Zhu

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