Bioactive mesopore-glass microspheres with controllable protein-delivery properties by biomimetic surface modification

Journal of Biomedical Materials Research. Part a
Chengtie WuYin Xiao

Abstract

Microsphere systems with the ideal properties for bone regeneration need to be bioactive, and at the same time possess the capacity for controlled protein/drug-delivery; however, the current crop of microsphere system fails to fulfill these properties. The aim of this study was to develop a novel protein-delivery system of bioactive mesoporous glass (MBG) microspheres by a biomimetic method through controlling the density of apatite on the surface of microspheres, for potential bone tissue regeneration. MBG microspheres were prepared by using the method of alginate cross-linking with Ca(2+) ions. The cellular bioactivity of MBG microspheres was evaluated by investigating the proliferation and attachment of bone marrow stromal cell (BMSC). The loading efficiency (LE) and release kinetics of bovine serum albumin (BSA) on MBG microspheres were investigated after coprecipitating with biomimetic apatite in simulated body fluids (SBF). The results showed that MBG microspheres supported BMSC attachment and the Si-containing ionic products from MBG microspheres stimulated BMSCs proliferation. The density of apatite on MBG microspheres increased with the length of soaking time in SBF. BSA-LE of MBG was significantly enhanced by coprecip...Continue Reading

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Citations

Mar 1, 2012·Journal of Materials Science. Materials in Medicine·Jasmin Hum, Aldo R Boccaccini
May 27, 2011·Journal of the Royal Society, Interface·Chengtie WuGianaurelio Cuniberti
May 2, 2014·Journal of Controlled Release : Official Journal of the Controlled Release Society·Chengtie Wu, Jiang Chang
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Apr 15, 2011·Injury·Josh E Schroeder, Rami Mosheiff
Apr 14, 2012·Journal of Biomedical Materials Research. Part a·Tao LuoYufeng Zhang
Jun 11, 2015·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Gurbinder KaurDaniel Homa
Jun 5, 2015·Materials Science & Engineering. C, Materials for Biological Applications·A AngelopoulouG Kordas
Jun 12, 2016·Materials Science & Engineering. C, Materials for Biological Applications·Ying ZhangWenxing Zhong
Jul 12, 2012·Journal of Biomaterials Applications·Chengtie WuYin Xiao
Dec 19, 2016·European Journal of Cell Biology·Sajjad SisakhtnezhadHassan Akrami
Nov 21, 2015·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Nan LiYongsheng Li
Apr 15, 2019·Journal of Materials Science. Materials in Medicine·Xiaoyan WangLong Liu
Apr 14, 2016·Materials·Charlotte Vichery, Jean-Marie Nedelec
Feb 21, 2013·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Chengtie WuJiang Chang
Feb 21, 2014·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Sai Prakash MaddalaAlice C Sullivan
Aug 12, 2017·Journal of Applied Biomaterials & Functional Materials·Wai-Ching LiuTien-Min G Chu
Jun 5, 2021·Journal of Controlled Release : Official Journal of the Controlled Release Society·Smriti GuptaSairam Krishnamurthy

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