Bioactive metabolites from the endophytic fungus Ampelomyces sp. isolated from the medicinal plant Urospermum picroides

Phytochemistry
Amal H AlyRainer Ebel

Abstract

Extracts of cultures grown in liquid or on solid rice media of the fungal endophyte Ampelomyces sp. isolated from the medicinal plant Urospermum picroides exhibited considerable cytotoxic activity when tested in vitro against L5178Y cells. Chromatographic separation yielded 14 natural products that were unequivocally identified based on their 1H and 13C NMR as well as mass spectra and comparison with previously published data. Six compounds (2, 4, 5, 7, 9 and 11) were natural products. Both fungal extracts differed considerably in their secondary metabolites. The extract obtained from liquid cultures afforded a pyrone (2) and sulfated anthraquinones (7 and 9) along with the known compounds 1, 3, 6 and 8. When grown on solid rice medium the fungus yielded three compounds 4, 5 and 11 in addition to several known metabolites including 6, 8, 10, 12, 13 and 14. Compounds 4, 8 and 10 showed the strongest cytotoxic activity against L5178Y cells with EC50 values ranging from 0.2-7.3microg/ml. Furthermore, 8 and 10 displayed antimicrobial activity against the Gram-positive pathogens, Staphylococcus aureus, S. epidermidis and Enterococcus faecalis at minimal inhibitory concentrations (MIC) of 12.5microg/ml and 12.5-25microg/ml, respectiv...Continue Reading

References

Dec 19, 2002·Critical Reviews in Biotechnology·Gary A Strobel
Apr 7, 2005·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·F Menichetti
Aug 23, 2006·Marine Biotechnology·Theresa Fuk Ning KwongPei Yuan Qian
Nov 28, 2006·Journal of Natural Products·Mohamed AshourPeter Proksch

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Citations

Mar 5, 2013·The Journal of Microbiology·Tiago de Souza LeiteMarisa Vieira de Queiroz
Apr 13, 2012·Journal of Agricultural and Food Chemistry·JinTong ZhaoChengBo Gu
Jan 27, 2012·Journal of Natural Products·Cai-Juan ZhengChang-Yun Wang
Mar 17, 2011·Journal of Asian Natural Products Research·Lin ZhangJiao Bai
Dec 24, 2011·Genetics and Molecular Research : GMR·P Y ZengK-H Wong
Jun 21, 2014·Brazilian Journal of Microbiology : [publication of the Brazilian Society for Microbiology]·Elissandro Fonseca Dos BanhosPatrícia Melchionna Albuquerque
Mar 22, 2014·Natural Product Reports·Antonio EvidenteRobert Kiss
Aug 20, 2014·Journal of Natural Products·Xue-Ming ZhouZhi-Gang Niu
Dec 24, 2014·Letters in Applied Microbiology·P D MishraG Kelter
Feb 26, 2011·Biotechnology Research International·Mariana Recco PimentelGláucia Maria Pastore
May 23, 2015·Frontiers in Microbiology·Irailton Prazeres Dos SantosVera Lucia de Menezes Lima
Nov 25, 2011·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Yanhong WangXiaomin Wu
Oct 20, 2012·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Nataša Radić, Borut Strukelj
Dec 7, 2013·Natural Product Research·Aamer Saeed, Muhammad Qasim
Oct 1, 2016·Natural Product Research·Runlin CaiZhigang She
Oct 6, 2016·Frontiers in Microbiology·Ahmed M Abdel-AzeemLamiaa M Farghaly
Jun 23, 2020·Natural Product Research·Mona M G SaadYoshihito Shiono
Jun 26, 2013·Prikladnaia biokhimiia i mikrobiologiia·N N GesslerT A Belozerskaia
Sep 5, 2020·Natural Product Research·Jinyan ZhangXinzhou Yang
Jan 23, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ahmad Omar NoorSabrin Ragab Mohamed Ibrahim
Mar 12, 2019·Natural Product Research·Jiao LiWen Zhang
Jul 16, 2020·Plants·Mustafa MorsyHayden Armuelles-Millican
Nov 29, 2020·Bioorganic & Medicinal Chemistry·Dina H El-KashefPeter Proksch
Jan 5, 2021·Russian Journal of Bioorganic Chemistry·A A BaranovaA P Tyurin
Mar 8, 2021·Archives of Microbiology·Adekunle Raimi, Rasheed Adeleke
Mar 11, 2009·Journal of Natural Products·Abdessamad DebbabRainer Ebel
Jun 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Yuanwei LiuJaya Seelan Sathiya Seelan

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