Bioactive Novel Indole Alkaloids and Steroids from Deep Sea-Derived Fungus Aspergillus fumigatus SCSIO 41012

Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry
Salendra LimbadriYong-Hong Liu

Abstract

Two new alkaloids, fumigatosides E (1) and F (2), and a new natural product, 3, 7-diketo-cephalosporin P₁ (6) along with five known compounds (3⁻5, 7, 8) were isolated from deep-sea derived fungal Aspergillus fumigatus SCSIO 41012. Their structures were determined by extensive spectroscopic data analysis, including 1D, 2D nuclear magnetic resonance (NMR) and mass spectrometry (MS), and comparison between the calculated and experimental electronic circular dichroism (ECD) spectra. In addition, all compounds were tested for antibacterial and antifungal inhibitory activities. Compound 1 showed significant antifungal activity against Fusarium oxysporum f. sp. momordicae with MIC at 1.56 µg/mL. Compound 4 exhibited significant higher activity against S. aureus (16,339 and 29,213) with MIC values of 1.56 and 0.78 µg/mL, respectively, and compound 2 exhibited significant activity against A. baumanii ATCC 19606 with a MIC value of 6.25 µg/mL.

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Citations

Feb 7, 2020·Natural Product Reports·Anthony R CarrollMichèle R Prinsep
Jul 17, 2020·Natural Product Reports·Zoe E Wilson, Margaret A Brimble
Jun 20, 2020·Archiv der Pharmazie·Yang LiuGuishun Piao
Jun 24, 2020·Antibiotics·Thomas WillemsWim K Soetaert
Jan 5, 2021·Russian Journal of Bioorganic Chemistry·A A BaranovaA P Tyurin
Nov 7, 2020·European Journal of Medicinal Chemistry·Mariana C AlmeidaEmília Sousa
Sep 29, 2020·Mini Reviews in Medicinal Chemistry·Syed ShabanaA Krishna Satya

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Methods Mentioned

BETA
NMR
circular dichroism
X-ray
column chromatography

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Aspergillosis is the name given to a wide variety of diseases caused by infection by fungi of the genus Aspergillus. Aspergillosis occurs in chronic or acute forms which are clinically very distinct. Most cases of acute aspergillosis occur in patients with severely compromised immune systems. Chronic colonization or infection can cause complications in people with underlying respiratory illnesses. Discover the latest research on aspergillosis here.

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