Bioactive Phenolic and Isocoumarin Glycosides from the Stems of Homalium paniculiflorum

Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry
Shou-Yuan WuXiao-Ping Song

Abstract

Two new phenolic glycosides (1 and 2) and two new isocoumarin glycosides (3 and 4), along with 14 known compounds (5-18), were isolated from the stems of Homalium paniculiflorum. Their structures were established on the basis of extensive spectroscopic analyses and chemical methods. All new compounds were evaluated for their anti-inflammatory activities via examining the inhibitory activity on nitric oxide (NO) production induced by lipopolysaccharide (LPS) in mouse macrophage RAW 264.7 cells in vitro. Compounds 1 and 4 exhibited inhibitory activities with IC50 values of 30.23 ± 1.23 μM and 19.36 ± 0.19 μM, respectively.

References

May 1, 1993·Journal of Natural Products·O A EkaboV Reutrakul
Jul 19, 2013·Pharmaceutical Biology·Jude E OkokonMohammed Iqbal Choudhary
Sep 8, 2015·Fitoterapia·Chung Sub KimKang Ro Lee

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Citations

Jan 10, 2019·Evidence-based Complementary and Alternative Medicine : ECAM·Yuqin ZhangWei Xu
Mar 31, 2021·Chinese Journal of Natural Medicines·Shou-Yuan WuXiao-Ping Song

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Methods Mentioned

BETA
column chromatography
Assay

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