Bioactive polybrominated diphenyl ethers from the marine sponge Dysidea sp

Journal of Natural Products
Hui ZhangLeng Chee Chang

Abstract

A new polybrominated diphenyl ether ( 9), together with eight known compounds, were isolated from the crude organic extract of the marine sponge Dysidea sp. collected from the Federated States of Micronesia. Their structures were elucidated on the basis of various NMR spectroscopic data. These compounds exhibited inhibitory activities against Streptomyces 85E in the hyphae formation inhibition (HFI) assay and displayed antiproliferative activities against the human breast adenocarcinoma cancer cell line MCF-7. Compound 6 was selected for further evaluation in a cell cycle progression study.

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Citations

May 18, 2013·Chemical Reviews·Sandip B BharateRam A Vishwakarma
Mar 28, 2009·Journal of Natural Products·Laurent CalculPhillip Crews
Jan 7, 2015·Environmental Science & Technology·Vinayak AgarwalBradley S Moore
Feb 25, 2018·The Journal of Animal Ecology·Pieter T J JohnsonJacobus C de Roode
Jan 30, 2010·Natural Product Reports·John W BluntMichèle R Prinsep
Mar 7, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Laura SchmittSebastian Wesselborg
Sep 3, 2009·Journal of Natural Products·David E WilliamsRoberto G S Berlinck

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