Bioactive stilbenes from a Bacillus sp. N strain associated with a novel rhabditid entomopathogenic nematode

Letters in Applied Microbiology
S N KumarC Mohandas

Abstract

The aim of the present study was to purify and characterize a natural antimicrobial compound from Bacillus sp. strain N associated with a novel rhabditid entomopathogenic nematode. The cell-free culture filtrate of a bacterium associated with a novel entomopathogenic nematode (EPN), Rhabditis (Oscheius) sp. exhibited strong antimicrobial activity. The ethyl acetate extract of the bacterial culture filtrate was purified by column chromatography, and two bioactive compounds were isolated and their chemical structures were established based on spectral analysis. The compounds were identified as 3,4',5-trihydroxystilbene (1) and 3,5-dihydroxy-4-isopropylstilbene (2). The presence of 3,4',5-trihydroxystilbene (resveratrol) is reported for the first time in bacteria. Compound 1 showed antibacterial activity against all the four test bacteria, whereas compound 2 was effective against the Gram-positive bacteria only. Compounds 1 and 2 were active against all the five fungi tested and are more effective than bavistin, the standard fungicide. The antifungal activity of the compounds against the plant pathogenic fungi, Rhizoctonia solani is reported for the first time. Cell-free extract of the bacterium and isolated stilbenes demonstrated...Continue Reading

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Citations

Jul 19, 2012·World Journal of Microbiology & Biotechnology·S Nishanth KumarC Mohandas
Oct 15, 2013·Applied Biochemistry and Biotechnology·S Nishanth Kumar, Bala Nambisan
Aug 15, 2015·Applied Microbiology and Biotechnology·Tim A SchönerHelge B Bode
Mar 19, 2019·Microbiology·Alexia HapeshiNicholas Robin Waterfield
Oct 9, 2018·Current Medicinal Chemistry·Francisco Javier Álvarez-MartínezVicente Micol
Jul 8, 2017·Planta·A S Dubrovina, K V Kiselev
Mar 9, 2018·Frontiers in Pharmacology·Dexter S L MaBey-Hing Goh
Jun 24, 2020·Antibiotics·Luce Micaela MattioAndrea Pinto
Apr 10, 2019·Current Medicinal Chemistry·Iolanda Francolini, Antonella Piozzi
Sep 28, 2017·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Narjess BostanghadiriAli Hashemi

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