PMID: 11933022Apr 5, 2002Paper

Bioactive taxoids from the Japanese yew Taxus cuspidata

Medicinal Research Reviews
J Kobayashi, Hideyuki Shigemori

Abstract

A series of new taxoids, named taxuspines A-H and J-Z (1-25) and taxezopidines A-H and J-L (26-36), have been isolated together with 37 known taxoids (37-73) including paclitaxel (53) from the Japanese yew, Taxus cuspidata Sieb. et Zucc. (Taxaceae). These new taxoids possess various skeletons containing 5/7/6, 6/10/6, 6/5/5/6, 6/8/6, or 6/12-membered ring systems. Among the new taxoids, some non-taxol-type compounds remarkably reduced CaCl(2)-induced depolymerization of microtubules, or increased cellular accumulation of vincristine in multidrug-resistant tumor cells as potent as verapamil. On the other hand, chemical derivatization of taxinine (37), one of major taxoids obtained from this yew, led to the discovery of unusual reactions of taxinine derivatives. Here we describe our recent results on the isolation, structure elucidation, and bioactivity of these new and known taxoids and the formation of unexpected products of the unusual reactions of taxinine.

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Citations

Jan 28, 2006·Natural Product Research·Qing-Wen ShiHiromasa Kiyota
Jul 6, 2005·Chemical & Pharmaceutical Bulletin·Ya-Ching ShenYuan-Bin Cheng
Oct 17, 2013·Chemistry & Biodiversity·Yong LiQing-Wen Shi
Dec 29, 2006·Chemistry & Biodiversity·Cong-Mei CaoHiromasa Kiyota
Oct 21, 2009·Chemistry & Biodiversity·Yu-Fang WangQing-Wen Shi
Jul 27, 2010·Chemistry & Biodiversity·Yu-Fang WangQing-Wen Shi
Dec 29, 2006·Chemistry & Biodiversity·Qing-Wen Shi, Hiromasa Kiyota
Aug 6, 2020·Frontiers in Microbiology·Yanjie LiuXudong Zhu
Aug 24, 2010·Chemistry & Biodiversity·Ming ChengQing-Wen Shi
Apr 26, 2003·Journal of Natural Products·Qing-Wen ShiLolita O Zamir
Oct 6, 2011·Chemical Reviews·Yu-Fang WangBin Cong
Feb 28, 2004·Journal of Natural Products·Hideyuki Shigemori, Jun'ichi Kobayashi

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