Bioactive triterpenoids from Atriplex lasiantha

Journal of Asian Natural Products Research
Basharat AliMuhammad Saleem

Abstract

Chromatographic purification of the ethyl acetate soluble fraction from the methanolic extract of Atriplex lasiantha yielded a new triterpenoid, 7β,15α,16β-trihydroxyolean-12-ene-28,30-dioic acid-3-O-β-D-xylopyranoside (1), along with two known triterpenoids, rotundifolioside I (2) and corchorusin B (3). Structures of the compounds 1-3 were elucidated through sophisticated NMR studies and high resolution mass spectrometry. The three isolates (1-3) were evaluated for antibacterial, antioxidant, and antiurease activities. Compound 2 exhibited the best antibacterial activity against Escherichiacoli with IC50 value of 66.25 μg/ml, whereas, all the tested compounds exhibited antioxidant (IC50 values of 68.7-75.4 μg/ml) and antiurease (IC50 values of 25.5-49.3 μg/ml) activities, respectively.

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Citations

Feb 15, 2020·Natural Product Reports·Robert A Hill, Joseph D Connolly
Mar 28, 2018·Experimental and Therapeutic Medicine·Mohammad K ParvezSyed Rafatullah

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Methods Mentioned

BETA
NMR
H
column chromatography
ELISA

Software Mentioned

Excel
Fit Enzyme Kinetics
EZ

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