Bioactivities and Medicinal Value of Solanesol and Its Accumulation, Extraction Technology, and Determination Methods

Biomolecules
Ning YanZhongfeng Zhang

Abstract

Solanesol, an aliphatic terpene alcohol composed of nine isoprene units, is mainly found in solanaceous plants. Particularly, tobacco (Nicotiana tabacum), belonging to the Solanaceae family, is the richest plant source of solanesol, and its leaves have been regarded as the ideal material for solanesol extraction. Since the discovery of solanesol in tobacco, significant progress has been achieved in research on solanesol's bioactivities, medicinal value, accumulation, extraction technology, and determination methods. Solanesol possesses strong free radical absorption ability and antioxidant activity owing to the presence of several non-conjugated double bonds. Notably, solanesol's anti-inflammatory, neuroprotective, and antimicrobial activities have been previously demonstrated. Solanesol is a key intermediate in the synthesis of coenzyme Q10, vitamin K2, and the anticancer agent synergiser N-solanesyl-N,N'-bis(3,4-dimethoxybenzyl) ethylenediamine. Other applications of solanesol include solanesol derivative micelles for hydrophobic drug delivery, solanesol-derived scaffolds for bioactive peptide multimerization, and solanesol-anchored DNA for mediating vesicle fusion. Solanesol accumulation in plants is influenced by genetic an...Continue Reading

References

Sep 21, 1977·Journal of Chromatography·R F SeversonA I Schepartz
Oct 3, 2002·Japanese Journal of Cancer Research : Gann·Hideki EnokidaMasayuki Nakagawa
Mar 28, 2006·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Hua-Ying Zhou, Chun-Zhao Liu
Feb 24, 2007·Journal of Pharmaceutical and Biomedical Analysis·Chunjian ZhaoYuangang Zu
Mar 19, 2009·Physiologia Plantarum·Agnieszka BajdaEwa Swiezewska
May 25, 2010·Biochemical and Biophysical Research Communications·Magnus BentingerGustav Dallner
Jul 21, 2010·Biochemical Pharmacology·Ananta PaineStephan Immenschuh
Aug 13, 2010·The Journal of Organic Chemistry·Ramesh AlletiEugene A Mash
Apr 5, 2011·Phytochemistry·Mark A Taylor, Paul D Fraser
Apr 10, 2012·Progress in Molecular Biology and Translational Science·Zhiqiang Zheng, Marc I Diamond
Sep 10, 2013·Trends in Biochemical Sciences·Matthias P Mayer
Oct 5, 2013·Journal of Clinical Densitometry : the Official Journal of the International Society for Clinical Densitometry·Maryam S HamidiAngela M Cheung
Nov 29, 2013·Journal of Labelled Compounds & Radiopharmaceuticals·Stephen J RoeAndrew Baxter
Nov 4, 2015·Current Drug Metabolism·Alvaro SarmientoJulio J Ochoa
Mar 20, 2016·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Xiaoqin MaMin Xue
Jul 21, 2016·Critical Reviews in Food Science and Nutrition·Julia Khéde Dourado VillaHércia Stampini Duarte Martino
Sep 10, 2016·Frontiers in Plant Science·Raymond CampbellMark A Taylor
Nov 18, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ning YanYanhua Liu
Dec 22, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Chemical Basis Of The Fungicidal Activity Of Tobacco Extracts Against Valsa Mali Suzhen DuanZhongfeng Zhang
Mar 24, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ning YanZhongfeng Zhang
Apr 19, 2017·Journal of Agricultural and Food Chemistry·Benkai QinGuang Han
Jun 26, 2017·Biophysical Journal·Kristina M Flavier, Steven G Boxer
Jan 19, 2019·Biomolecules·Ning YanZhongfeng Zhang
Apr 27, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Marija BanožićStela Jokić
May 3, 2019·Heliyon·Marjan ArabFariba Dehghani

❮ Previous
Next ❯

Citations

Apr 29, 2021·Transgenic Research·Margit DrapalPaul D Fraser
Nov 14, 2020·International Journal of Molecular Sciences·Carmen J Pastor-MaldonadoJosé A Sánchez-Alcázar
Jul 25, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Danqing XieWencui Wang

❮ Previous
Next ❯

Methods Mentioned

BETA
light scattering

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.