Bioactivity and mineralization of hydroxyapatite with bioglass as sintering aid and bioceramics with Na3 Ca6 (PO4 )5 and Ca5 (PO4 )2 SiO4 in a silicate matrix

Materials Science & Engineering. C, Materials for Biological Applications
Hande DemirkiranPranesh Aswath

Abstract

Hydroxyapatite and Bioglass®-45S5 were sintered together creating new ceramic compositions that yielded increased apatite deposition and osteoblast differentiation and proliferation in vitro compared to hydroxyapatite. The sintered products characterized by X-ray diffraction, revealed hydroxyapatite as the main phase when small quantities (1, 2.5 and 5wt.%) of bioglass was added. Bioglass behaved as a sintering aid with β-TCP (Ca3(PO4)2) being the minor phase. The amount of β-TCP increased with the amount of bioglass added. In compositions with larger additions of bioglass (10 and 25wt.%), new phases with compositions of calcium phosphate silicate (Ca5(PO4)2SiO4) and sodium calcium phosphate (Na3Ca6(PO4)5) were formed respectively within amorphous silicate matrices. In vitro cell culture studies of the ceramic compositions were examined using bone marrow stromal cell (BMSC). Cell proliferation and differentiation of bone marrow stromal cells into osteoblasts were determined by Pico Green DNA assays and alkaline phosphatase (ALP) activity, respectively. All hydroxyapatite-bioglass co-sintered ceramics exhibited larger cell proliferation compared to pure hydroxyapatite samples. After 6days in cell culture, the ceramic with Ca5(PO...Continue Reading

Citations

May 14, 2017·Journal of Tissue Engineering and Regenerative Medicine·Natascia CozzaClaudio Migliaresi
Jul 8, 2017·Journal of Biomedical Materials Research. Part a·M RizwanW J Basirun
Dec 10, 2015·Journal of Biomedical Materials Research. Part a·Devis BellucciValeria Cannillo
Nov 2, 2019·Bioactive Materials·Joy-Anne N OliverDonghui Zhu

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