Bioactivity-guided fractionation of the lipoxygenase and cyclooxygenase inhibiting constituents from Chisocheton polyandrus Merr

Fitoterapia
Kit Yee ChanLip Yong Chung

Abstract

Lipoxygenase (LOX)-inhibiting compounds from the leaves of Chisocheton polyandrus Merr. were isolated in this study using a bioactivity-guided fractionation technique. Two dammarane triterpenoids, dammara-20,24-dien-3-one (1) (IC(50)=0.69±0.07 μM) and 24-hydroxydammara-20,25-dien-3-one (2) (IC(50)=1.11±0.38 μM), were isolated and identified based on the soybean LOX assay. Dammara-20,24-dien-3-one (1) exhibited dual inhibition of both human 5-LOX (IC(50)=24.27±2.92 μM) and cyclooxygenase-2 (COX-2) (IC(50)=3.17±0.90 μM), whereas 24-hydroxydammara-20,25-dien-3-one (2) did not exhibit any significant inhibitory effects. This report is the first to detail the inhibition of LOX and COX by both C. polyandrus and its isolated compounds.

References

Feb 28, 1998·Biochimie·S T PriggeL M Amzel
Mar 22, 2000·Biological & Pharmaceutical Bulletin·Y OzakiY T Tang
Nov 8, 2003·The Journal of Pharmacy and Pharmacology·J M PrietoJ L Ríos
May 6, 2004·Bioorganic & Medicinal Chemistry Letters·Dieter ScholzJosef G Meingassner
Jul 29, 2004·Mini Reviews in Medicinal Chemistry·C Michaux, C Charlier
Jan 3, 2006·Journal of Plant Physiology·Alena Liavonchanka, Ivo Feussner
Mar 6, 2007·Bioorganic & Medicinal Chemistry Letters·Mingfang ZhengHualiang Jiang
Mar 30, 2007·Archives of Biochemistry and Biophysics·H G MaheshaA G Appu Rao
Apr 24, 2007·Phytotherapy Research : PTR·Huaping ZhangMichael J Wargovich
Feb 19, 2008·Archives of Pharmacal Research·Jarinporn PhongmaykinEkarin Saifah
Dec 17, 2008·Cardiovascular & Hematological Disorders Drug Targets·Natalia Bunimov, Odette Laneuville
Dec 17, 2008·Bioorganic & Medicinal Chemistry·Khalit MohamadHiroshi Morita
Dec 1, 2009·Journal of Natural Products·Ming-Hua YangLing-Yi Kong
May 25, 2010·Biochemical and Biophysical Research Communications·Olof Rådmark, Bengt Samuelsson

❮ Previous
Next ❯

Citations

Mar 13, 2016·Chemistry & Biodiversity·Jamil A ShilpiKhalijah Awang
Aug 17, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Jingya RuanTao Wang
Dec 23, 2016·Medicinal Research Reviews·Catarina Pereira-LeiteSalette Reis
Aug 21, 2018·Advances in Pharmacological Sciences·Fazleen Izzany Abu BakarAsmah Rahmat
Dec 3, 2016·Molecular Diversity·Mengdi ZhangAixia Yan
Nov 28, 2019·Journal of Natural Products·Nhu Ngoc Quynh VoEry Odette Fukushima

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anti-inflammatory Treatments

A drug or substance that reduces inflammation (redness, swelling, and pain) in the body. Anti-inflammatory agents block certain substances in the body that cause inflammation and swelling. Discover the latest research on anti-inflammatory treatments here

Asthma

This feed focuses in Asthma in which your airways narrow and swell. This can make breathing difficult and trigger coughing, wheezing and shortness of breath.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.

Related Papers

Journal of Natural Medicines
Chin Piow WongHiroshi Morita
Journal of Natural Products
Ibrahim A NajmuldeenHiroshi Morita
Bioorganic & Medicinal Chemistry Letters
Dieter ScholzJosef G Meingassner
Annals of the New York Academy of Sciences
J C BoyingtonS M Yuan
© 2021 Meta ULC. All rights reserved