PMID: 19943487Dec 1, 2009Paper

Bioactivity guided isolation of alpha-glucosidase inhibitor from whole herbs of Crossostephium chinense

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica
Qi WuDe-Xian Fu

Abstract

To investigate the chemical constituents of 70% aqueous ethanol extract from the whole plant of Crossostephium chinense for inhibitory activity against alpha-glucosidase. A bioactivity-guided isolation and purification process was used to identify the alpha-glucosidase activity inhibiting components of the whole plant of C. chinense. The dried whole plants were extracted with 70% aqueous ethanol. The extract was suspended in water and then further fractionated successively with cyclohexane, ethyl acetate, and normal butanol,and tested for their inhibitory activity against alpha-glucosidase in vitro. The chemical structures of isolated compounds were determined by spectroscopic methods including NMR and MS, and comparison with data of authentic samples. All of compounds were assayed for their inhibitory activity against alpha-glucosidase in vitro. The ethyl acetate and water layer fractions showed the strong inhibitory activity, and were subjected to column chromatography over the various stationary phases. Tricetin 3',4',5'-trimethylether (1), scopoletin (2), tanacetin, hispidulin (3), apometzgerin (4), chrysoeriol (5), quercetagetin 3,6, 7-trimethylether (6), selagin (7) , scopolin (8), and quercetagetin-3,6-dimethylether (9) ...Continue Reading

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