Bioactivity of Circulatory Factors After Pulmonary Exposure to Mild or Stainless Steel Welding Fumes.

Toxicological Sciences : an Official Journal of the Society of Toxicology
Vamsi K KodaliAaron Erdely

Abstract

Studies suggest that alterations in circulating factors are a driver of pulmonary-induced cardiovascular dysfunction. To evaluate, if circulating factors effect endothelial function after a pulmonary exposure to welding fumes, an exposure known to induce cardiovascular dysfunction, serum collected from Sprague Dawley rats 24 h after an intratracheal instillation exposure to 2 mg/rat of 2 compositionally distinct metal-rich welding fume particulates (manual metal arc welding using stainless steel electrodes [MMA-SS] or gas metal arc welding using mild steel electrodes [GMA-MS]) or saline was used to test molecular and functional effects of in vitro cultures of primary cardiac microvascular endothelial cells (PCMEs) or ex vivo organ cultures. The welding fumes elicited significant pulmonary injury and inflammation with only minor changes in measured serum antioxidant and cytokine levels. PCME cells were challenged for 4 h with serum collected from exposed rats, and 84 genes related to endothelial function were analyzed. Changes in relative mRNA patterns indicated that serum from rats exposed to MMA-SS, and not GMA-MS or PBS, could influence several functional aspects related to endothelial cells, including cell migration, angioge...Continue Reading

References

Jan 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·J S StamlerJ Loscalzo
Oct 1, 1992·Free Radical Biology & Medicine·H EsterbauerG Jürgens
Dec 1, 1991·The Journal of Clinical Investigation·J L Witztum, D Steinberg
Jan 21, 1995·Lancet·A SeatonD Godden
Nov 5, 2002·International Journal of Occupational and Environmental Health·Bengt SjögrenJan Weiner
Feb 15, 2003·Critical Reviews in Toxicology·James M Antonini
Apr 25, 2003·Methods in Molecular Medicine·Ronald S Go, Whyte G Owen
Jul 2, 2003·Toxicological Sciences : an Official Journal of the Society of Toxicology·Michael D TaylorJames M Antonini
May 26, 2004·Computer Methods and Programs in Biomedicine·Rebecca J BlattAmy L Tucker
Feb 23, 2005·Occupational and Environmental Medicine·J Y KimD C Christiani
Apr 17, 2007·Toxicological Sciences : an Official Journal of the Society of Toxicology·J Grace WallenbornUrmila P Kodavanti
Jul 20, 2007·Environmental Health Perspectives·Jennifer M CavallariDavid C Christiani
Feb 14, 2008·Particle and Fibre Toxicology·Timothy R NurkiewiczVincent Castranova
Feb 28, 2008·Inhalation Toxicology·Jennifer M CavallariDavid C Christiani
Jul 11, 2008·Environmental Health : a Global Access Science Source·Jennifer M CavallariDavid C Christiani
Nov 26, 2008·Nature Clinical Practice. Cardiovascular Medicine·Nicholas L MillsDavid E Newby
Jan 21, 2009·American Journal of Epidemiology·Shona C FangDavid C Christiani
Jan 8, 2010·Kidney International·Hans OberleithnerHermann Schillers
Apr 17, 2010·Journal of Occupational and Environmental Hygiene·Lissinda du PlessisFritz Eloff
May 12, 2010·Circulation·Robert D BrookUNKNOWN American Heart Association Council on Epidemiology and Prevention, Council on the Kidney in Cardiovascular Disease, and Coun
Jun 17, 2011·Journal of Occupational and Environmental Medicine·Aaron ErdelyPetia P Simeonova
Aug 20, 2011·Current Opinion in Immunology·Greg M DelgoffeDario A A Vignali
Dec 24, 2011·Nature Protocols·Marianne BakerKairbaan Hodivala-Dilke
Sep 12, 2012·Current Opinion in Lipidology·Carlos ZaragozaMarta Saura
Jul 23, 2013·Toxicological Sciences : an Official Journal of the Society of Toxicology·Alex P CarllAimen K Farraj
Jun 3, 2014·Particle and Fibre Toxicology·Pascal AndujarSophie Lanone
Aug 16, 2014·Cardiovascular Toxicology·Christina M PerezAimen K Farraj

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiovascular Inflammation

Inflammation plays a significant role in the development of cardiovascular diseases, an understanding of these endogenous processes is critical for evaluating the risks and potential treatment strategies. Discover the latest research on cardiovascular inflammation here.

Cell Migration

Cell migration is involved in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. Here is the latest research.