Bioactivity Potential of Prunus spinosa L. Flower Extracts: Phytochemical Profiling, Cellular Safety, Pro-inflammatory Enzymes Inhibition and Protective Effects Against Oxidative Stress In Vitro

Frontiers in Pharmacology
Anna MarchelakMonika A Olszewska

Abstract

Flower extracts of Prunus spinosa L. (blackthorn)-a traditional medicinal plant of Central and Eastern Europe indicated for the treatment of urinary tract disorders, inflammation, and adjunctive therapy of cardiovascular diseases-were evaluated in terms of chemical composition, antioxidant activity, potential anti-inflammatory effects, and cellular safety in function of fractionated extraction. The UHPLC-PDA-ESI-MS(3) fingerprinting led to full or partial identification of 57 marker constituents (36 new for the flowers), mostly flavonoids, A-type proanthocyanidins, and phenolic acids, and provided the basis for authentication and standardization of the flower extracts. With the contents up to 584.07 mg/g dry weight (dw), 490.63, 109.43, and 66.77 mg/g dw of total phenolics (TPC), flavonoids, proanthocyanidins, and phenolic acids, respectively, the extracts were proven to be rich sources of polyphenols. In chemical in vitro tests of antioxidant (DPPH, FRAP, TBARS) and enzyme (lipoxygenase and hyaluronidase) inhibitory activity, the extracts effects were profound, dose-, phenolic-, and extraction solvent-dependent. Moreover, at in vivo-relevant levels (1-5 μg/mL) the extracts effectively protected the human plasma components agai...Continue Reading

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Citations

Mar 1, 2018·Pharmaceutical Biology·Emily Guzman, Jeanmaire Molina
Sep 29, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Agnieszka KicelMonika A Olszewska
Jun 20, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Izabela Grzegorczyk-Karolak, Anna K Kiss
Jan 29, 2021·Biomolecules·Melita LončarićMaja Molnar
Aug 12, 2021·Probiotics and Antimicrobial Proteins·L S SafronovaV M Ilyash
Jul 18, 2020·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Hammad UllahMaria Daglia

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Methods Mentioned

BETA
Protein Assay
ELISA

Software Mentioned

Satistica12Pl

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