Bioactivity profiling using HPLC/microtiter-plate analysis: application to a New Zealand marine alga-derived fungus, Gliocladium sp

Journal of Natural Products
Gerhard LangMurray H G Munro

Abstract

Using HPLC/microtiter-plate-based generation of activity profiles the extract of a marine alga-derived fungus, identified as Gliocladium sp., was shown to contain the known strongly cytotoxic metabolite 4-keto-clonostachydiol (1) and also clonostachydiol (2) as well as gliotide (3), a new cyclodepsipeptide containing several D-amino acids. The absolute configuration of 1 was elucidated by reduction to 2, and two further oxidized derivatives of clonostachydiol (5, 6) were prepared and evaluated for biological activity.

References

Feb 19, 2004·Magnetic Resonance in Chemistry : MRC·Ronald CrouchKrish Krishnamurthy
Jun 26, 2004·Journal of Natural Products·Christine KlemkeGabriele M König
Feb 5, 2005·Natural Product Reports·John W BluntMichele R Prinsep
Jun 1, 2005·Journal of Natural Products·Yuu KasaiJun'ichi Kobayashi

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Citations

Apr 9, 2011·Journal of Natural Products·Masahiko IsakaJ Jennifer Luangsa-ard
Dec 2, 2011·Journal of Natural Products·Tyler A JohnsonPhillip Crews
Jun 5, 2010·Journal of Natural Products·Moriah SandyAlison Butler
Feb 6, 2008·Natural Product Reports·John W BluntMichèle R Prinsep
Feb 27, 2014·The Journal of Antibiotics·Tatsuya Ito, Miyako Masubuchi
Feb 1, 2012·Journal of Biomedicine & Biotechnology·Nor Ainy MahyudinMurray H G Munro
Oct 23, 2012·Parasitology Research·Marcela Gamboa-AnguloManuela Reyes-Estebanez
Mar 29, 2012·Evidence-based Complementary and Alternative Medicine : ECAM·Carolina SantiagoJacinta Santhanam
Mar 11, 2016·Journal of Environmental Science and Health. Part C, Environmental Carcinogenesis & Ecotoxicology Reviews·Lien TaevernierBart De Spiegeleer
Jan 19, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Xiaohan WangLigang Zhou
Jan 14, 2011·Natural Product Reports·Mostafa E Rateb, Rainer Ebel
Apr 23, 2009·The Journal of Organic Chemistry·Junjie HanXinfu Pan
Dec 10, 2016·Journal of Agricultural and Food Chemistry·Tavane A AlvarengaPatrícia M Pauletti

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