Jan 11, 2014

Bioactivity screening of five Centaurea species and in vivo anti-inflammatory activity of C. athoa

Pharmaceutical Biology
Sura Baykan ErelCanan Karaalp

Abstract

Centaurea L. (Asteraceae) species used as herbal remedies in Turkish traditional medicine have shown several biological properties. Extracts obtained from the aerial parts of Centaurea aphrodisea Boiss., Centaurea athoa DC., Centaurea hyalolepis Boiss., Centaurea iberica Trev. and Centaurea polyclada DC. were evaluated for their antioxidant, cytotoxic and anti-inflammatory activities. Extracts of Centaurea species were tested for their antioxidant activity in the 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid (ABTS) screening assays and for in vitro anti-inflammatory activity by Nf-κB and iNOS inhibition assays. The extracts were tested for their in vitro cytotoxicities against a panel of human solid tumor cell lines (SK-MEL: malignant melanoma, KB: oral epidermal carcinoma, BT-549: breast ductal carcinoma and SK-OV-3: ovary carcinoma) as well as non-cancerous kidney fibroblast (Vero) and kidney epithelial cells (LLC-PK1) by Neutral Red assay. In vivo anti-inflammatory activity of C. athoa was evaluated by the carrageenan-induced paw edema test in rats. Antioxidant activities were observed for methanol extracts of plants. C. polyclada had the strongest effect on BT-549, KB and SK...Continue Reading

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Mentioned in this Paper

ISYNA1 gene
Centaurea iberica
Squamous Transitional Epithelial Cell Count
Anti-Inflammatory Agents
Ovarian Neoplasm
Antioxidants
Plant Components, Aerial
Neutral Red
NOS2 wt Allele
Carrageenan

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